Study of free radicals (malondialdehyde) in pre-eclampsia and eclampsia in correlation with uric acid and total proteins

Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 3

Abstract

Introduction Oxidative stress is a normal phenomenon in normotensive pregnancy however in preeclampsia oxidative stress is exaggerated may result in a greater potential for endothelial oxidative damage It has been reported that higher MDA Malondialdehyde total antioxidant capacity TAC ratio is indicative of oxidative stress in women with preeclampsiaMaterials and Methods Prospective study was done for duration of 2 years ie from January 2015 to December 2017 in the department of Biochemistry at Kakatiya Medical College Hanmakonda CKM hospital Warangal A total number of 60 pregnant women were included in the study Among these 20 pregnant women were clinically diagnosed as preeclampsia and 20 are eclamptic cases and the remaining 20 were selected as control group and are normotensive antenatal women who are also in third trimester of pregnancyResults The mean MDA serum uric acid 24 hr urinary protein were higher in preeclampsia and eclampsia compared to controlsConclusion Increased lipid peroxidation products levels clearly shows that oxidation stress is more in preeclampsia and eclampsia than in control subjects and it plays a significant role in etiopathogensis of PIH Serum uric acid levels are significantly higher in cases than in controls and by estimating the uric acid levels we can assess the severity of the disease and we can avoid further progress of the disease process by early detection and prompt treatment Total serum protein levels are drastically reduced in preeclampsia and eclampsia cases compared to controlsKeywords MDA Serum uric acid Proteins Eclampsia Preeclampsia

Authors and Affiliations

R. Kathyaini, T. Aruna Kumari

Keywords

Related Articles

Evaluation of serum magnesium and zinc levels in patients with Type 2 diabetes mellitus

Introduction: The complications of Type 2Diabetes, both microvascular and macrovascular develop at an early stage of life in Indian population. The reasons may be poor glycemic control and excessive loss of serum Mg and...

Oxidative stress and antioxidant status in coronary artery disease patients before percutaneous transluminal coronary angioplasty

Introduction: Oxidant lead to cell death through apoptosis and necrosis. The effects of reactive oxygen radicals are balanced by the antioxidant action. The aim of the study was to assess oxidative stress and antioxidant...

Status of pro-inflammatory Marker IL-6 and Microalbuminuria in type- 2 Diabetic Nephropathy subjects

Introduction: Diabetic nephropathy is a progressive renal complication of type-2 diabetes. Inflammation is found as main cause of diabetic nephropathy pathogenesis. Cytokines influence inflammatory and immune responses b...

D, L Glyceraldehyde- Will it be an effective Antiglycolytic Agent?

Aim: This study aimed to compare the effectiveness of D, L Glyceraldehyde (GLY) with Plain Sodium Fluoride (NaF) as an antiglycolytic agent and its interferences in the estimation of Serum creatinine by Modified Jaffe′s...

Assessment of Vitamin D status in Type 1 Diabetes Mellitus in pediatric age group

Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Type-1-Diabetes Mellitus (TIDM) results from autoimmune destruction of beta cells leading to insulin deficiency. Vitamin D d...

Download PDF file
  • EP ID EP475202
  • DOI 10.18231/2394-6377.2018.0096
  • Views 52
  • Downloads 0

How To Cite

R. Kathyaini, T. Aruna Kumari (2018). Study of free radicals (malondialdehyde) in pre-eclampsia and eclampsia in correlation with uric acid and total proteins. International Journal of Clinical Biochemistry and Research, 5(3), 453-457. https://www.europub.co.uk/articles/-A-475202