Study of Hodgkin Lymphoma with Special Reference to NLPHL in A Tertiary Care Hospital in Eastern India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 7
Abstract
Abstract:Hodgkin lymphoma is one of the most common lymphomas in the developed world. There is a great importance of histological sub classification of Hodgkin lymphoma so far prognostic importance is concerned. Moreover, PTGC may proceed to the development NLPHL and at present an overlap between NLPHL and TCRLBCL cannot be excluded. So a detailed clinical and morphological study is essential in Hodgkin lymphoma to assess proper diagnosis and prognosis. As there is scarcity of study in this field in Eastern India, our study was performed. Forty known cases of Hodgkin lymphoma was studied with detailed clinical history, examination findings, routine histopathological examination with IHC correlation (CD20, CD3. CD30, CD15). Special emphasis is given on T cell (CD3) infiltration in NLPHL. Out of 40 cases, 3 were NLPHL, 25 were NSCHL, 9 were MCCHL, 2 were LRCHL and 1 was LDCHL. Two cases of NLPHL showed 8 to 10% of T cell (CD3 positive) infiltration in the background. One case of NLPHL showed 50 to 60% T cell positivity in the background suggesting close follow up to rule out progression to TCRLBCL. Our study was done to asses these important prognostic parameters in Hodgkin lymphoma. However study involving more number of cases will be more informative. Keywords:Hodgkin lymphoma, CD 20, CD3, CD30, CD15, NLPHL, Tcell.
Authors and Affiliations
Soma Sabui, Sucharita Sarkar, Rames RanjanHaldar
Keywords
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