STUDY OF HYPOMAGNESAEMIA IN CRITICALLY-ILL PATIENTS IN MEDICAL INTENSIVE CARE UNIT AT TERTIARY CARE HOSPITAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 67
Abstract
BACKGROUND Magnesium is the second most abundant intracellular cation and the fourth most common cation in the body. The effect of magnesium on important biological processes such as glycolysis, oxidative phosphorylation, nucleotide metabolism, protein biosynthesis signifies the importance of magnesium in cellular metabolism. Magnesium plays a role in numerous enzymatic processes in the body and has direct role in activation of enzymes such as phosphofructokinase, creatine kinase, acetylate cyclase and sodium potassium ATPase. The aim of the study is to1. Study serum magnesium level in critically-ill patient. 2. Correlate serum magnesium level with patient outcomes. 3. Identify primary medical conditions and the factors predisposing or contributing to abnormalities of serum magnesium. MATERIALS AND METHODS Study of 100 cases admitted over a period of 2 years, i.e. between 2010 to 2012 in MICU at SSG Hospital, Vadodara. The patient admitted for critical illness in ICU was included in study. The patients who received magnesium before admission to MICU were excluded from study. A blood sample was collected for estimation of serum total magnesium level on admission to MICU. History and clinical finding were noted for each patient, other haematological, biochemical and radiological investigations were performed as indicated in every patient. RESULTS 66% were male and 34% were female patients. Hypomagnesaemia was found in 52%, normal level in 41% and hypomagnesaemia in 7%. Present study shows mortality and sepsis were statistically significant findings in study population, i.e. in patients with hypomagnesaemia (p<0.05). Statistically significant correlation was found with hypocalcaemia and hypoalbuminaemia in study populations (p<0.05). However, hypomagnesaemia doesn’t show significant association with duration of MICU stay, need of ventilator. CONCLUSION Hypomagnesaemia is a one of electrolyte imbalance in the critically-ill patients. Hypomagnesaemia is associated with higher mortality rate in critically-ill patients as Mg plays important role in homeostasis. Morbidity and mortality in critically-ill patient has relation with low Mg level. However, potential benefits of Mg supplementation to prevent or correct hypomagnesaemia in critically-ill patients require further study.
Authors and Affiliations
Sumit Kamble, Hetal Patel, Smita Trivedi
Keywords
Related Articles
- EP ID EP271999
- DOI 10.18410/jebmh/2017/805
- Views 101
- Downloads 0
A CASE CONTROL STUDY OF THE ASSOCIATION OF VAGINAL INFECTIONS WITH PRETERM LABOUR AND NEONATAL OUTCOME
BACKGROUND Prematurity accounts for 85% of neonatal mortality. The neonatal morbidity associated with preterm labour is also very high. About 40% of unexplained preterm labour is due to vaginal infections. Screening for...
HYPOCALCEMIA IN POST CAESAREAN PATIENT PRESENTING AS ACUTE GASTRIC DILATION
Even though Acute Gastric Dilation is rarely encountered complication, if not diagnosed early and treated promptly can lead on to catastrophic events very rapidly. The causal factor for most such cases are benign, hence...
THE STUDY OF NUTRIENT FORAMINA IN HUMAN CLAVICLE
BACKGROUND The major blood supply to the long bones is through nutrient arteries, which enter the medullary cavity of bone through the nutrient foramina. Nutrient foramen is the opening present in the shaft of long bone....
A STUDY ON CLINICOPATHOLOGICAL SPECTRUM OF OVARIAN TUMOURS IN A TERTIARY CARE CENTRE
BACKGROUND Ovarian cancer is the 6 th most common cancer in worldwide among female population, whereas in India, it is the third most common cancer among women, 1 in 70 women have their lifetime risk to develop this tumo...
A COMPARATIVE STUDY OF FIXATION OF DISTAL END FRACTURES OF FEMUR BY SUPRACONDYLAR NAIL AND DYNAMIC CONDYLAR SCREW
AIMS AND OBJECTIVES: To study the functional outcome of fractures of distal end of femur in adults surgically treated with supracondylar nail and Dynamic condylar screw. To study the complications of Dynamic Condylar scr...