Study of Insulin Resistance by Homeostatic Model Assessment (Homa) in Type 2 Diabetes Mellitus Patients and Its Correlation with Diabetic Nephropathy
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 2
Abstract
Abstract: Many studies showed that Insulin resistance is present in chronic renal failure and evidences suggest that Insulin resistance can also occur in early stages of renal disease. In Indian Scenario there is paucity of data available, so this study was conducted to establish relationship between Insulin Resistance with various stages of Diabetic nephropathy, if any. Study subjects and methods: This is cross sectional study where total 100 subjects are included and are divided into three groups according to their renal status, Group 1 (control) n=19, group 2 (Normoalbuminuria) n=21, group 3 (Microalbuminuria) n=39 and group 4 (Macroalbuminuria) n=21. Seem Insulin measurement was estimated by chemiluminescence method. Insulin resistance was calculated using Homeostatic Model Assessment (HOMA method). The normal cut off value for HOMA IR (2.4) was derived using mean+2SD of control group. Subjects on Insulin therapy was kept in exclusion crieteria. Results: Mean HOMA IR increased significantly with decreasing renal function. Larger percentage of subjects had HOMA IR (≥2.4) at different stages of diabetic kidney disease (Normo albuminuria: 60%; Microalbuminuria: 76%, Microalbuminuria: 92%) compared to normal (32%). There was no significant difference between the study groups with respect to age, BMI, duration of diabetes, duration of nephropathy, habits, glycemic control. The results of multiple logistic regression analysis showed an association between HOMA IR and diabetic nephropathy. Conclusion: There is an association between Insulin Resistance and diabetic kidney disease in type 2 diabetes. In day to day practice clinicians must think about insulin resistance in diabetic patients. It should be measured in all the diabetic patients because it is cheap and easily measurable from FPI and fasting blood sugar level. Its measurement will help to prevent the development of various complications of diabetes at early stages.
Authors and Affiliations
Dr. Sushama Jotkar, Dr. Sangram Deshmukh
Keywords
Related Articles
- EP ID EP474128
- DOI -
- Views 63
- Downloads 0
Association of CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia
The CYP17 gene encodes for the Cytochrome P450c17ɑ enzymes 17ɑ hydroxylase, 17-20 lyase in testosterone synthesis. There is a polymorphism (T to C substitution) in the 5’ untranslated region of CYP17 gene, providing an i...
Study of Fine Needle Aspiration Cytology of Thyroid Lesions by Morphometry
Fine Needle Aspiration Cytology (FNAC) is used as the screening procedure for thyroid nodules. FNAC utilizes size of cell and nuclei and shape of cells as a criterion for diagnosis and helps in the diagnosis of malignant...
Comparative Study of Harmonic Scalpel versus Electrocautery in MRM
Abstract:Breast cancer is one of the most common carcinoma in the female population. Several combinations of surgery, radiotherapy, chemotherapy and hormonal immunotherapy are being used for treatment of carcinoma breast...
Study of Parasympathetic Function Tests during Different Phases of Menstrual Cycle
Abstract: Autonomic nerve function status may be changed during follicular and late lutealPhases of menstrual cycle due to fluctuations of serum estrogen and progesterone levels. This Alteration in autonomic nerve functi...
Isolation and Sensitivity of Bacteria Caused Urinary Tract Infections at Wasit Province
Abstract: One hundred - twenty samples collected from patients infected with acute and chronic urinary tract infection in different hospitals of Wasit Province. Seventy five bacterial isolates, which were then, diagnosed...