Study of Mast cells in non neoplastic skin lesions – study on 72 cases
Journal Title: Perspectives In Medical Research - Year 2016, Vol 4, Issue 2
Abstract
Introduction: Skin, the largest external organ of human body, is associated with a gamut of lesions. Clinical manifestations include erythema, itching, edema, swelling, vesicles, bullae, alterations in pigmentation etc. Mast cell is an integral cellular component of skin and is believed to respond to diverse range of stimuli. Mast cells can regulate tissue changes that confer either a beneficial or a harmful effect depending upon specific circumstances. In the present study, an attempt is made to evaluate mast cell profile (density) in various non neoplastic skin lesions. No attempt is made to assess their role in different cutaneous disorders. Material and Methods:A prospective analytical histopathological study of non-neoplastic skin lesions was carried out during June 2004 –May 2005. A total of seventy two cases were included in this study. Results: Irrespective of category, lesions of bullous mastocytosis showed highest mast cell density and the lowest numbers were seen in scleroderma Conclusion: Majority of inflammatory lesions, infective and non-infective, showed definite changes in mast cell numbers and distribution patterns (like perivascular and interstitial) when compared to normal skin controls. Lesions with epidermal involvement showed increased number of mast cells in superficial dermis and lesions with dermal involvement showed dermal predominance of mast cells.
Authors and Affiliations
Prashanth Kumar M
Keywords
Related Articles
- EP ID EP306824
- DOI -
- Views 142
- Downloads 0
Neurological manifestations in peripartum period
Introduction: Several neurological diseases are unique to pregnancy and postpartum period . Some disorders increase in prevalence during this period. Objective :To study the clinical profile of patients presenting with...
Postnatal quality of life: A neglected research area in India
World Health Organization defines Quality of Life (QOL) as “individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectation...
Clinicopathological study of Ovarian tumours
Introduction: The ovary consists of sex cells, which are totipotential and of mesenchymal cells which are multipotential.So when it becomes neoplastic almost any type of tumour can result. The ovarian tumours manifest as...
Consanguinity and its effects: The Love that dare not speak its surname
Introduction: Consanguineous marriage means marrying biologically related or blood relatives. Consanguinity is a deeply rooted trend in the South Indian States. Aims and Objectives : The aim of the study is to determin...
Management and Outcomes of Emphysematous Pyelonephritis – A study of 34 cases
Objective: : Emphysematous pyelonephritis (EPN) is a severe, necrotizing infection of the renal parenchyma; it causes gas formation within the collecting system, renal parenchyma, and/or perirenal tissues . Gas in the re...