Study of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory marker for diabetic nephropathy in type 2 diabetic patients
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 7
Abstract
<strong>Background: </strong>Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. DN in T2DM has an inflammatory pathology. Many inflammatory markers have been found to be related to DN, such as interleukin1 (IL1), IL6, IL8, transforming growth factor beta 1(TGF-β1) and tumor necrosis factor alpha (TNF α). However, their measurement is not used routinely as it is not easy to do it, in this respect. Search for inflammatory markers for the disease is a continuous process to enhance the diagnostic and treatment process. <strong>Aim of the Work: </strong>To assess neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory markers for diabetic nephropathy in type 2 diabetic patients. <strong>Patients and Methods: </strong>This study is a prospective one that was carried out on one hundred (100) type 2 Diabetes mellitus (T2DM) patients attending to internal medicine outpatient clinic and inpatient department of internal medicine at Al-Azhar university hospital, Damietta and twenty five (25) apparently healthy volunteers as a control. The populations of the study were classified into three groups according to their level of albuminuria. All were subjected tofull history and Clinical examination, Laboratory tests include Fasting mid-stream urine samples were obtained and examined for complete urine analysis and albumin/creatinine ratio (UACR),Complete blood count (CBC), HbA1c,Fasting blood sugar, Renal Function Tests,eGFR and Abdominal ultrasonography, Fundus examination and ECG and Assessment of NLR &PLR. <strong>Results: </strong>Our study showed that there was high statistically significant increased NLR, PLR and UACR in group IB when compared to group IA, II and III. Also there was statistically significant increased NLR,PLR and UACR in group IA in comparison to group II and also there was statistically significant increased NLR,PLR and UACR in group II in comparison to group III. <strong>Conclusion: </strong>Neutrophil lymphocyte ratio (NLR) & Platelet lymphocyte ratio (PLR) was significantly associated with diabetic nephropathy (DN) and high Neutrophil lymphocyte ratio (NLR) & Platelet lymphocyte ratio (PLR) values may be considered as a predictor and a prognostic risk markers of diabetic nephropathy (DN).
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP584242
- DOI 10.12816/ejhm.2018.10137
- Views 126
- Downloads 0
Futures and the outcome of treatment of poisoned children and adolescents admitted to emergency units in different areas of Saudi Arabia
<strong>Background: </strong>poisoning is a major problem in the pediatric and adolescents population. Poisoning is a main reason for children’s admission to emergency units. Medications are the most common poisonous age...
Role of Automated Breast Ultrasound System (ABUS) as Screening Tool in Comparison To Mammogram in Detect of Different Breast Lesions
<span>Background: </span><span>Mammography is an effective randomized controlled trial-proven method for reducing mortality due to breast cancer. However, the sensitivity of mammography depends on breast density. The cur...
Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery
<strong>Objective:</strong> To assess the efficacy of tranexamic acid in reduction of blood loss and pervention of postpartum hemorrhage after vaginal delivary. <strong>Methods:</strong> This is a multicentric prospectiv...
First Line Management of Adult Diabetic Ketoacidosis Patients
Abstract Background:Diabetic Ketoacidosis (DKA) is a hyperglycemic crisis that can occur in patients with both type 1 and 2 diabetes mellitus. It is a medical emergency with a significant morbidity and mortality. It is h...
Congenital Extra-Cardiac Vascular Anomalies as Detected on Multislice Computed Tomography Angiography
<strong>Background: </strong>Accurate evaluation of extra cardiac and intra cardiac anomalies in congenital heart diseases (CHD) is vital for diagnosis and treatment. Trans-thoracic echocardiography (TTE) is the classica...