Study of oxidative stress and endothelial dysfunction in paediatric obesity
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2016, Vol 3, Issue 4
Abstract
Introduction: Obesity is associated with complications like Diabetes, Asthma, Hypertension and cardiovascular risks which are to be managed of health care worldwide. Increased BMI during childhood and adolescence may lead to premature death from disease and may increase the risk of CVD at adult age. Methods: 30 obese children with an age group of 8-15 years attending paediatric department and 30 healthy age matched non obese children were taken in the study. BMI was calculated for all and biochemical markers like fasting blood glucose, Insulin resistance (HOMA-IR) were determined using commercial enzymatic kits. MDA, FRAP, and NO was determined by chemical methods. Results: A significant increased levels of BMI, Insulin and insulin resistance (HOMA-IR), MDA and NO levels (P<0.05) was observed in obese children compared to non-obese but, the levels of Fasting blood sugar levels and FRAP were not statistically significant in cases compared to controls. Conclusions: As childhood obesity can influence many risk factors like diabetes, hypertension, asthma, endothelial dysfunction which may lead to CVD risk and atherosclerosis most of the studies reported that there are possible chances to minimize these risk factors by proper medication and most of the events are even reversible. Therefore the parent should be suggested to have a proper dietary management and medication in order to avoid the progression of these risk factors in adulthood.
Authors and Affiliations
Sarala Devi Tenepalli, Karunasree Yerrajwala, Lalitha Devi Seerla
Keywords
Related Articles
- EP ID EP243127
- DOI -
- Views 113
- Downloads 0
Evaluation of clinical biochemistry laboratory performance using sigma metrics
Producing a reliable reproducible accurate timely and correctly interpreted test results by clinical laboratory is very important since physicians decisions mostly depends on it for screening diagnosis and monitoring dis...
A study of interaction of cigarette smoke with alpha-1 antitrypsin and adenosine deaminase in patients of chronic obstructive pulmonary diseases (COPD) and antioxidant role of vitamin E
Lungs are the only organs which are continuously exposed to external environment through the process of breathing The cigarette smoking is main leading cause of various morbidities related to lungs Adenosine deaminase AD...
Role of biomarker of Oxidative stress in preeclampsia
Objective: To evaluate the role of biomarker of oxidative stress in predilection of pregnancy induced hypertension. Material and Methods: A sample of 200 pregnant women was examined at department of Gynecology and obstet...
Speculation of diabetic nephropathy by pro-inflammatory cytokines (IL-6, IL-10) & renal biomolecules
Introduction: Type 2 diabetic nephropathy (T2DN) develops inflammation in kidney which leads to failure. Study designed to evaluate risk of diabetic nephropathy (DN) by inflammatory gene expressions (IL6, IL10) and renal...
Association of serum electrolyte with renal function, in diabetes mellitus - a pilot study
Introduction: Decompensated diabetes mellitus with impaired renal function, acid-base disorders are often associated with electrolyte imbalance. Analysis of electrolytes is often advised without a true indication in Diab...