Study of oxidative stress in women with preeclampsia
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Root cause of preeclampsia is placental ischemia due to impaired trophoblastic invasion in uterine spiral arterioles. Ischemic placenta liberates various inflammatory mediators. Inflammation is associated with development of free radicals leading to vascular endothelial damage. Therefore estimation of oxidative stress can give insight to pathogenesis of disease. Objectives: To compare oxidative stress among women with preeclampsia & normal pregnancy. Materials and Method: Thirty pre-eclamptic women and thirty women with normal pregnancy were included in study as cases and controls respectively. Serum levels of MDA, vitamin C & uric acid were estimated. Data was compared using unpaired student’s t-test done by SPSS 17.0 software. Results: Cases were having significantly higher serum MDA levels than controls. There were significantly lower serum levels of vitamin C & uric acid in cases than controls (p<0.05). Conclusions: Significantly increased level of MDA & decreased level of Vitamin C & uric acid in pre-eclamptic mothers suggests that increased oxidative stress and preeclampsia are associated with each other. Elevated oxidative stress is independent risk factor for vascular diseases so it can be used as a biomarker to identify women at risk.
Authors and Affiliations
Amit D. Sonagra, Asmabi Makandar, Zahoorunissa Deba, Shylaja TV, K. Dattatreya
Keywords
Related Articles
- EP ID EP297181
- DOI 10.18231/2394-6377.2017.0057
- Views 62
- Downloads 0
Association between urine albumin creatinine ratio and high sensitivity C-reactive protein in patients with type 2 diabetes mellitus
Introduction Diabetes mellitus is one of the leading causes of morbidity and mortality for its association with complications like nephropathy neuropathy retinopathy and cardiovascular diseases Chronic inflammation plays...
Dyslipidemia correlating with reduced glomerular filtration rate in apparently healthy individuals
There are many studies relating the renal dysfunction with dyslipidemia. This study intended to assess the correlation of estimated glomerular filtration rate (eGFR) with the lipid levels in apparently healthy individual...
Prevalence of metabolic syndrome in obese medical students –a case control study
Introduction: The Metabolic Syndrome is a constellation of risk factors predictive of future Cardio Vascular Accidents (CVA) and Type 2 Diabetes Mellitus (T2DM) in adults. Recently several studies revealed that metabolic...
Fractional excretion of sodium (FENa): A paraphernalia in incipient nephropathy versus overt nephropathy in Type I Diabetes Mellitus
An estimated 40% of patients diagnosed with Type I diabetes and 5 - 15% of patients with Type II diabetes eventually develop ESRD and diabetes has become the leading cause (44%) of end-stage renal disease in India. There...
C-Peptide and insulin levels in patients of metabolic syndrome
Metabolic Syndrome (MetS) is cluster of physical conditions and metabolic abnormalities commonly found in association with increased risk for development of type-2 diabetes mellitus (T2DM), cardiovascular disease (CVD)...