Study of Pattern of Emerging Antifungal Resistance in A Zonal Hospital in North-East India.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Introduction: Superficial fungal infections of skin are common worldwide. The etiological agents are varied with emerging resistance pattern especially among azoles. The present study aims to demonstrate the current trend of anti fungal resistance among superficial mycoses using the method of disk diffusion in a peripheral hospital. Materials and Methods: This prospective study was done at a Government zonal hospital from Nov 2015 to Nov 2016. 135 consecutive OPD patients of the department of Dermatology clinically diagnosed to have a fungal infection of skin and then confirmed on KOH mount were included. Skin scrapings were cultured on SDA and differential media. Isolate and identified species were further subjected to anti fungal sensitivity test using Itraconazole, Fluconazole, Ketoconazole and Voriconazole by the Disk diffusion method. Results: Both dermatophyte and non dermatophyte fungi were isolated and identified in the cultures. Antifungal resistance was marked for Fluconazole and Ketoconazole. Conclusion: Epidemiological variance found in etiological agents is in resonance with the geographical location of our study. Resistance was rampant to both Fluconazole and Ketoconazole which are commonly used as first line anti fungal drugs. Itraconazole and Voriconazole had lesser degree of resistance. Culture and identification of causative organism is a must in superficial mycoses. Disk diffusion as an accepted method of antifungal sensitivity test must be encouraged. The relative ease of the method coupled with its reliability and cost effectiveness would go a long way in establishing anti fungal resistance testing as a routinely done investigation even in remote areas.
Authors and Affiliations
Amit Bahuguna MD, Arpitha Pemmarajub MD, JR Galagalic MS
Keywords
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- EP ID EP591717
- DOI 10.9790/0853-1602032427.
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