Study of platelet indices in hyperlipidemia
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 4
Abstract
Introduction Atherosclerosis is a chronic inflammatory condition n resulting from hyperlipidemia and involves platelet mediated recruitment of white blood cells to arteries The platelet activation is measured indirectly through several platelet indices routinely available without any additional cost in newer fully automated haematology analysers These indices include platelet count mean platelet volumeMPV platelet distribution widthPDW plateletcritPCT mean plateletcomponent concentration MPC mean platelet dry mass MPM platelet large cell count and platelet large cell ratio PLCR The present study was undertaken in the pathology department of our diagnostic centre to find an association between platelet indices reported by Advia 2120Siemens fully automated haematology analyser and hyperlipidemiaMaterials and Methods This was a prospective study carried out in our diagnostic centre from April to July 2018 100 patients with hyperlipidemia without any associated diseases and 100 controls with normal lipid profile were included in the study Statistical analysis was done using Pearsons correlation test and data was expressed as mean SD for each parameter A p value of 0Results Maximum number of patients were in 4160 years of age 65 The male to female ratio was 17 1 with 63 males and 37 females The mean cholesterol mean triglyceride and mean HDL cholesterol level in study group was 2186363 244315438796 respectively and 158268 941348and 42193 in control group respectively Mean LDL cholesterol was 1311394 in study group and 971252 in control group There was a significant difference in platelet counts in both groups with a p value of 001 PCT and MPC also showed a p value of 0004 The mean platelet mass MPM was 21702 in study group as compared to 213021 in control group Large platelet count was 70949 in study group while it was 595381 in control group which was also significantly differentConclusion Our study indicates that PCT MPM large platelets and platelet count are significantly higher in hyperlipidemia patientsThese indices are available without any additional cost to clinicians pathologists and patients and can be used to assess the risk associated with hyperlipidemiaKeywords Hyperlipidemia MPV Plateletcrit MPC MPM PLCR
Authors and Affiliations
Ranjana Hawaldar, Sadhna Sodani
Keywords
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- EP ID EP482794
- DOI 10.18231/2581-3706.2018.0061
- Views 134
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