Study of Serum Apolipoprotein A1 and Apolipoprotein B100 in Ischemic Heart Disease
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 5
Abstract
Background: Apolipoprotein A1 (Apo A1), the major apoprotein in HDL promotes reverse cholesterol transport producing an antiatherogenic effect in body. Apolipoprotein B100 (Apo B100) a major apolipoprotein of LDL has atherogenic property. The aim of the study is to evaluate concentrations of Apo A1 & Apo B100 in ischemic heart disease patients and healthy controls and also to establish the inter-relationships between Apo A1 & Apo B100 among the patients. Methods: A case control study carried out from October 2014 to August 2016 in the Department of Biochemistry in collaboration with Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur. 60 ischemic heart disease (IHD) patients and 60 healthy controls were taken as the study population. The results were analysed by ELISA. Results: The results of this study agree with the previous findings of other studies that the serum levels of Apo A1 & Apo B100 are significantly altered between IHD patients and controls. However, no significant correlation has been found between these three cardiac biomarker in this study. Apolipoprotein B100 measurements provide useful information for IHD risk assessment. Conclusion: The present data considers the measurement of Apo B100 as an important screening tool for the risk assessment of ischemic heart disease. Therefore, this study suggests the need for routine measurement of Apo A1 & Apo B100 in the diagnosis of IHD and thus helps in early detection of myocardial damage which warrants timely intervention leading to lowered morbidity and mortality.
Authors and Affiliations
L. Shaini, Soumya Sharma, Sachin Deba, Tina Das, Victoria Laishram, Salam Rojen Singh
Keywords
Related Articles
- EP ID EP547545
- DOI 10.21276/ijmrp.2017.3.5.027
- Views 108
- Downloads 0
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