Study of serum Cystatin C, beta-2 microglobulin and protein carbonyl in diabetic nephropathy
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 3
Abstract
Aim: Diabetic nephropathy is the leading cause of mortality due to long term uncontrolled hyperglycaemia related complications.The aim of present study was to evaluate clinical values of serum Cys-C and 2 microglobulin and protein carbonyl as a marker of renal dysfunction and accompanied oxidative stress in diabetes mellitus patients. Material and Methods: A total of 47 consecutive diabetic nephropathy patients (age > 40 years) attending the Diabetic OPD and dialysis unit at Sir J.J. Hospital were included in the study. Serum creatinine, Cystatin C, β-2 microglobulin, Total protein and Albumin, Urea, Uric acid and protein carbonyl, HbA1c, fasting and post prandial glucose were measured. Glomerular Filtration Rate (GFR) was calculated using formula by National Kidney Foundation calculator, for both creatinine and Cystatin C and the grade of kidney disease and risk of progression was graded as1 : Stage 1 : Mild; 2 : Stage 2: moderate; 3: Stage 3: high; 4: Stage 4: very high. P value of < 0.05 was considered statistically significant. Unpaired t test and Pearson correlation was used to data analysis using SPSS statistical software (version 19.0). Results: The GFR was significantly higher in male compared to the female (p<0.01). Protein carbonyl and β- 2 microglobulin were significantly higher in female compared to the male group (p <0.08 and 0.02).The correlation of serum uric acid and protein carbonyl were stronger when Chronic Kidney Disease (CKD) severity when calculated using serum Cystatin C (r= 0.30 and 0.37 respectively) as compared to serum creatinine value based GFR (0.48 and 0.64 respectively).Serum Cystatin C showed significant correlation (r=0.35) with β- 2 Microglobulin while serum creatinine was not found to be correlated with beta-2 Microglobulin. Conclusions: Cystatin C and β2 microglobulin can serve as an early and accurate marker of renal function as compared to serum creatinine in patients with diabetes mellitus induced nephropathy.
Authors and Affiliations
Nilanjana Guha Niyogi, S P Dandekar, Shalini Maksane, V W Patil, L G Abichandani
Keywords
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