Study of serum Cystatin C, beta-2 microglobulin and protein carbonyl in diabetic nephropathy
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 3
Abstract
Aim: Diabetic nephropathy is the leading cause of mortality due to long term uncontrolled hyperglycaemia related complications.The aim of present study was to evaluate clinical values of serum Cys-C and 2 microglobulin and protein carbonyl as a marker of renal dysfunction and accompanied oxidative stress in diabetes mellitus patients. Material and Methods: A total of 47 consecutive diabetic nephropathy patients (age > 40 years) attending the Diabetic OPD and dialysis unit at Sir J.J. Hospital were included in the study. Serum creatinine, Cystatin C, β-2 microglobulin, Total protein and Albumin, Urea, Uric acid and protein carbonyl, HbA1c, fasting and post prandial glucose were measured. Glomerular Filtration Rate (GFR) was calculated using formula by National Kidney Foundation calculator, for both creatinine and Cystatin C and the grade of kidney disease and risk of progression was graded as1 : Stage 1 : Mild; 2 : Stage 2: moderate; 3: Stage 3: high; 4: Stage 4: very high. P value of < 0.05 was considered statistically significant. Unpaired t test and Pearson correlation was used to data analysis using SPSS statistical software (version 19.0). Results: The GFR was significantly higher in male compared to the female (p<0.01). Protein carbonyl and β- 2 microglobulin were significantly higher in female compared to the male group (p <0.08 and 0.02).The correlation of serum uric acid and protein carbonyl were stronger when Chronic Kidney Disease (CKD) severity when calculated using serum Cystatin C (r= 0.30 and 0.37 respectively) as compared to serum creatinine value based GFR (0.48 and 0.64 respectively).Serum Cystatin C showed significant correlation (r=0.35) with β- 2 Microglobulin while serum creatinine was not found to be correlated with beta-2 Microglobulin. Conclusions: Cystatin C and β2 microglobulin can serve as an early and accurate marker of renal function as compared to serum creatinine in patients with diabetes mellitus induced nephropathy.
Authors and Affiliations
Nilanjana Guha Niyogi, S P Dandekar, Shalini Maksane, V W Patil, L G Abichandani
Keywords
Related Articles
- EP ID EP176434
- DOI -
- Views 166
- Downloads 0
Epidemiological study of fracture of proximal humerus in adult at tertiary care centre
Background: Proximal humerus fracture (PHF) is the second most common fracture of upper extremity. For better clinical management and to reduce comorbidities and mortality, it is essential to survey and map the character...
A study of relationship between the keratometric and refractive astigmatism in pseudophakia
Introduction: The goal of current refractive cataract surgery is an excellent uncorrected visual acuity (UCVA) in all fixation ranges, which requires a zero postoperative refractive astigmatism (RA). This goal may be rea...
Brachial plexus schwannoma - A case report
Schwannomas are benign nerve sheath tumours arising from Schwann cells. Most of them arise in head and neck region and usually involve cranial nerves and sympathetic chain. Only 5% of the Schwannoma arise from brachial p...
A study on breast feeding practices in Raigarh district of Chhattisgarh, INDIA
Background: Breast feeding has been accepted as the most vital intervention for reducing infant mortality and ensuring optimal growth and development of child. It is the ideal method for the physiological and psychologic...
Correlation of high sensitivity C-reactive protein (hs-CRP) and HDL cholesterol in healthy south Indian individuals
Introduction: Measurement of high sensitivity C-reactive protein (hs-CRP) and High-density lipoprotein cholesterol (HDL-C) level both are predictive of future of cardiovascular diseases (CVD). However, studies correlatin...