Study of serum glucose and cholesterol level in schizophrenic patient’s before and after treatment of olanzapine, risperidone and haloperidol
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 3
Abstract
Objectives To evaluate the potential association between antipsychotics Olanzapine Risperidone and Haloperidol serum glucose level and serum cholesterol level in schizophrenic patientsIntroduction Schizophrenia is quite prevalent and has high rate of chronicity and morbidity Newer atypical antipsychotic drugs were developed in response to limitations such as lack of efficacy and side effects associated with older conventional agents However significant hyperglycemia dyslipidemia and weight gain have been reported with the use of newer atypical antipsychoticsMaterials and Methods This was an observational prospective study Total 75 schizophrenic patients were divided in three groups according to treatment allocated group I olanzapine group II risperidone group III haloperidol comprising of 25 patients in each group Blood sample was collected when patient came to hospital for the first time before starting the treatment and 6 weeks after treatment then again 6 months after treatment fasting serum glucose and cholesterol levels were estimated by enzymatic procedure Simultaneously body weight was also measuredResults In this study majority of patients were male7333 with mean age of 3076 years There were significant increase in serum glucose levels and serum cholesterol level after 6 weeks and 6 months of treatment t311 pt365 p 0 t311Conclusion Olanzapine was associated with increased risk of glucose intolerance dyslipidemia and weight gainKeywords Antipsychotics Schizophrenia Cholesterol Diabetes Weight gain
Authors and Affiliations
Vinod Koshley, Ajay Kumar Halwai, Rajesh Hishikar, Basant Maheshwari, Usha Joshi
Keywords
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- EP ID EP478563
- DOI 10.18231/2393-9087.2018.0031
- Views 90
- Downloads 0
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