Study of the intrauterine aerosol “Cefthiosol” tolerance to bovine cattle

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Study of the intrauterine aerosol “Cefthiosol” tolerance to bovine cattle

Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2018, Vol 32, Issue

Abstract

Introduction. The study of tolerance of the new medicinal product «Cefthiozol» for intrauterine use helps to study the mechanism of its action, the effect on the morpho-functional state of the target animals’ organism that can predict and prevent the adverse reaction. The goal of the work of the work was to study the tolerance of the preparation «Cefthiozol», with the active substance cefthiofur hydrochloride, under the conditions of test article administration to bovine cattle at elevated level. Materials and methods. The research was carried out on twenty heifers of the Aberdeen-Angus breed of 9 to 11 months old in the state enterprise «Experimental farm «Tuchinske», Rivne oblast. The animals of the first group were control. Animals of groups II, III, IV and V the preparation «Cefthiozol» were given intrauterinous, as cefthiofur hydrochloride at a dose of 1, 2, 5 and 10 mg cefthiofur hydrochloride per kg of weight per day, respectively, 3 times with an interval of 48 hours. Blood from animals was taken on the 1st, 3rd and 7th day of the experiment. Heparinized blood was used for hematological studies, blood sera – to determine biochemical parameters according to generally accepted methods. Results of research and discussion. It was established that at daily examination significant, visible changes in behavior and appetite of experimental group animal, compared with the control group animals were not observed. Clinical scores in animals of all groups were within the physiological norm. Deviations in the performance status of heifers of experimental groups, except for the appearance of diarrhea in some animals, which lasted no more than 1-2 days after stopping the administration of the preparation, were not observed. The increase in the volume of the uterus, the descensus of the horns and the body of the uterus were not observed in animals of group II, but were observed in one animal of group III, in four animals of groups IV and V, which is a normal individual physiological local reaction of the organism to the introduction of the increased amount of foreign substance, and a larger volume of gas, and does not affect the general physiological state of the animals. The volume and physiological position of the uterus normalized independently after the termination of the preparation administration. The received hematological and biochemical blood parameters of the control and experimental groups animals were within the physiological norm limits. Conclusions and prospects for further research. The new aerosol medication «Cefthiozol» when applied to bovine cattle intrauterinous for 3 times with an interval of 48 hours in doses exceeding 2-10 times the recommended therapeutic dose, is tolerant. The preparation does not cause significant adverse reaction when administered to the uterus, a negative effect on the overall clinical status of cows and changes in the morpho-functional state of their body. Further research will be aimed at completing pre-registration clinical trials of the aerosol preparation «Cefthiozol».

Authors and Affiliations

Roman Sachuk

Keywords

postpartum infection cefthiofur hydrochloride tolerance clinical status bovine cattle «Cefthiozol» antimicrobial effect

EP ID EP406161
DOI 10.31073/vet_biotech32(2)-58
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