Study of Thyroid Hormones in Male Infertility
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 9
Abstract
Hormones are one of the principal factors in intercellular and inter-organ communication. The thyroid hormones are crucial for normal functioning because of their control over body’s basal metabolic rate, as well as growth, development, and differentiation of many cells/organs in the body.The present study was based on a cross-sectional study design carried out at the outpatient department of Maheshwara Medical College & Hospital from January 2017 to July 2018. Serum levels of free thyroxin (FT4), thyroid stimulating hormone (TSH), free testosterone, prolactin (PRL), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured using immunoassay commercial kits in both groups. The normal reference ranges for thyroid hormones were as follows: TSH, 0.3 to 5.0 IU/mL and T4, 4.5 to 12.5 g/dL. Erectile dysfunction was evaluated using International Index of Erectile Function (IIEF-5) questionnaire. The results were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including age, serum levels of hormones, sperm parameters, and IIEF-5 scores, were assessed by sample t test.In our present study, age of hypothyroid subject group and normal control group is found to be non-significantly related (P = .367). Similarly, no significant relation was also noted among the FSH levels (P = .834) of the two groups. There was significant (P < .001) relation among the hypothyroid and normal groups in IIEF-5 scores, Serum PRL level, sperm count, sperm motility and morphology. Abnormal thyroid function resulted in decreased male fertility and/or impaired sexual activity. In hypothyroid subjects, high levels of PRL may affect sexual drive and result in occurance of Erectile Dysfuction. Thyroxin administration can improve fertility and reverses the effects of hormonal abnormalities. These observations show that sexual dysfunctions are almost always multifactorial (physical and psychological factors). In the present study, patients with hypothyroidism had significantly higher level of serum PRL and lower IIEF-5 score; the Serum levels of FSH, LH and free testosterone were not significantly different among the two groups. Overall, hypothyroidism linked with male infertility by adversely resulting in erectile dysfunction and semen quality.
Authors and Affiliations
Dr. K. Sudhakar Naidu, Dr. K. Ranjith Babu, Dr. K. Madhurima Naidu
Keywords
Related Articles
- EP ID EP480094
- DOI -
- Views 75
- Downloads 0
Obesity Influence on Lead levels in Blood and Scalp Hair among Teenage Smokers in Jordan
Increased incidence of obesity, cardiovascular disorder and smoking habit between teenagers in the undergraduate’s society has highlighted on the putative role of metals in the development of chronic disorders in urban a...
Prevalence of Pulmonary Hypertension among Non-Dialysis and Dialysis Dependent Chronic Kidney Disease Patients in a Tertiary Care Hospital
Abstract: Chronic kidney disease leads to many co morbidities that affects patients at all stages of the disease. Complications are due to disease itself as well as the mode of renal replacement therapy. Cardiovascular m...
Evaluation of Indirect markers of Sepsis for the Diagnosis of Neonatal Septicaemia
Neonatal sepsis is a serious condition resulting from the effects of severe bacterial infection in the first month of life. The clinical diagnosis of neonatal sepsis is difficult due to nonspecific signs and symptoms. Th...
Reasons Behind the Repeated Defaulted From the Pulmonary Tuberculosis Treatment under Revised National Tuberculosis Control Programme
The effectiveness of India’s TB control programs depend critically on patient compliance and completion of full course of treatment. Discontinuing treatment prior to completion of treatment, can leave patients infectious...
The Correlation between Placental Thickness and Fetal Age among the Pregnants in Sudan
The placenta is a fetal organ which provides the physiological link between pregnant woman and her fetus. The placenta is highly vascularized organ and its main functions are exchange of metabolic and gaseous products be...