STUDY ON C-REACTIVE PROTEIN IN CASES OF PRE-ECLAMPSIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 68
Abstract
BACKGROUND Pre-eclampsia is one of the most frequent obstetric complication occurring in about 5% to 10% of pregnancies. It is one of the leading causes of maternal and perinatal morbidity and mortality. C-reactive protein is a marker of tissue damage and inflammation and was proposed to play a role in eliciting the inflammatory response characteristic of pre-eclampsia. The objective of this study is- C-reactive protein, a sensitive marker of tissue damage and inflammation was proposed to play a role in eliciting the inflammatory response characteristic of preeclampsia. The present study is directed towards determining the association of serum C-reactive protein and preeclampsia. The aim of this study is this study on C-reactive protein in preeclampsia will serve as standard guideline for this part of the country. MATERIALS AND METHODS The study has been conducted in the Dept. of Obstetrics and Gynaecology, Patna Medical College and Hospital, Patna. Serum estimation of C-reactive protein was done in Dept. of Biochemistry in diagnosed cases of pre-eclampsia by turbidimetric method; 150 women of pre-eclampsia were selected as study group and 50 normotensive pregnant women were selected as control group. All women were in the age group of 20 - 35 yrs. and were in 3rd trimester of pregnancy. Statistical Analysis- Descriptive data were presented as mean SD and range values. Comparison between the control group and study group was done by Chi-square test. For all the tests, the probability value (p-value) of less than 0.05 was considered statistically significant. Study Design- Observational study. RESULTS The incidence of pre-eclampsia is higher in primi gravida and women of low socioeconomic status. The mean systolic blood pressure was of 117.88 mm of mercury in control group and 163.37 mm of mercury in study group. The mean diastolic blood pressure in control group was 74.44 mm of mercury and 108.50 mm of mercury in study group. Range of C-reactive protein was quite high in cases of the study group (30.12 - 90 mg/L) than the control group (2.2 - 16.15 mg/L). CONCLUSION Among various markers of inflammation in pre-eclampsia, C-reactive protein is strongly associated with inflammatory process and is a sensitive index of overall inflammatory activity in the body as CRP is markedly elevated in cases of pre-eclampsia.
Authors and Affiliations
Chitra Sinha, Ram Binay Sinha, Chander Kiran
Keywords
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- EP ID EP232632
- DOI 10.14260/Jemds/2017/1059
- Views 104
- Downloads 0
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