Study on the mechanism of losartan reducing the risk of comorbid depression in epileptic rats
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 2
Abstract
[Objective] To investigate the effectiveness and mechanisms of losartan in improving comorbid depression in epileptic rats. [Methods] Male rats were randomly divided into three groups: The losartan-pilocarpine group (PL-L) received intraperitoneal injection of lithium-pilocarpine to establish the epilepsy model, and then followed by losartan intervention. The pilocarpine group (PL) received intraperitoneal injection of lithium-pilocarpine to establish the epilepsy model. The control group (Ctrl) received intraperitoneal injection of lithium chloride. We used the body weight gain and sucrose preference test to analyze the behavior of rats in each group, and RT-PCR was used to examine the expression of High mobility group protein B1 (HMGB1)、interleukin-1β (IL-1β) and interleukin-6 (IL-6) mRNA in hippocampus of rats in each group. [Results] Compared to the Ctrl group, rats in the PL group showed significantly decreased body weight gain [(12.68±5.23) g vs. (41.08±15.87) g, P<0.01] and sucrose preference rate (53.85%±10.14% vs. (88.56%±16.53%, P<0.01). The expression of HMGB1 mRNA (4.17±1.23 vs. 1.00±0.02, P<0.01) was significantly increased. The expression of IL-1β (4.95±1.67 vs. 1.02±0.27, P<0.01) and IL-6 (2.75±1.20 vs. 1.01±0.19, P<0.05) were significantly increased too. Compared with the PL group, rats in the PL group showed significantly increased body weight gain [(37.97±10.24) g vs. (12.68±5.23) g, P<0.01] and sucrose preference rate (77.50%±7.35% vs. 53.85%±10.14%, P<0.05). The expression of HMGB1 (0.76±0.27 vs. 4.17±1.23, P<0.01) was significantly decreased. The expression of IL-1β (0.67±0.21 vs. 4.95±1.67, P<0.01) and IL-6 (0.95±0.27 vs. 2.75±1.20, P<0.05) mRNA were significantly decreased too. [Conclusion] Losartan can reduce the incidence of comorbid depression in epileptic rats, The possible mechanism is that losartan reduces HMGB1 release, so as to reduce the inflammatory factors (IL-1β, IL-6) in the hippocampus of rats. It can reduce the incidence of depression like behavior disorder in rats with epilepsy.
Authors and Affiliations
Nannan PAN, Yachun HU, Xuezhen LIAO, Zhe SHI, Haishan SHI
Keywords
Related Articles
- EP ID EP750427
- DOI 10.3969/j.issn.1002-0152.2024.02.005
- Views 41
- Downloads 0
Rapid progressive dementia and involuntary movement caused by vitamin B12 deficiency: a case report
A 41-year-old male was presented with rapidly progression memory impairment for 2 months and episodic limb shaking for 2 weeks as the main manifestations. Physical examination showed verbal disadvantage with decreased me...
An intervention study of Orff-music therapy for long-term hospitalized patients with schizophrenia
[Objective] This research aims to investigate the impact of Orff music therapy on long-term schizophrenic patients in hospitals. [Methods] The study was a randomized, single-blind controlled trial conducted from April,20...
The effect evaluation of revision operation for cubital tunnel syndrome followed surgical treatment
[Objective] To explore the causes of postoperative revision for cubital tunnel syndrome(CTS),summarize the details of revision surgery for CTS and evaluate the efficacy,in order to reduce the revision probability of the...
A case report of type II citrullinemia in an adult with epileptic seizure onset
A retrospective analysis was performed on one case of adult-onset type Ⅱcitrullinemia (CTLN2) caused by homozygous mutations of SLC25A13 genes. The patient, a 28-year-old male, had repeated limb convulsions for more than...
Analysis of risk factors of massive cerebral infarction after craniocerebral injury in children with acute subdural hematoma.
[Objective] To analyze and compare the clinical manifestations and imaging features of children with secondary massive cerebral infarction after acute subdural hematoma (ASDH), and to evaluate its potential risk factors...