STUDY THE EFFECT OF CO SOLVENT ON THE SOLUBILITY OF A SLIGHTLY WATER SOLUBLE DRUG
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2016, Vol 4, Issue 8
Abstract
The solubility of a drug depends upon the solvent. Hydrophilic drug are soluble in hydrophilic solvent while hydrophobic drugs are soluble in hydrophobic solvent, sometimes drugs contain both hydrophilic and hydrophobic part and single solvent that in sufficient to improve the solubility of drug is required. Frequently a soluble is more soluble in a mixture of solvents that in a single solvent alone, this phenomenon is known as co solvency and the solvent in combination increase the solubility of the solute is called the co solvents. The aim of present study was to study the effect of co solvents on the solubility of benzoic acid. From the graph it has been seen that the solubility of benzoic acid increases with the increased of concentration of co-solvent. When the straight line was extrapolated to Y axis, the intercept gives the solubility of benzoic acid in water.
Authors and Affiliations
Minakshi Verma*| Department of pharmacy, G.S.V.M. Medical College, Kanpur, Sudhir Singh Gangwar| Department of pharmacy, G.S.V.M. Medical College, Kanpur, Yatindra Kumar| Department of pharmacy, G.S.V.M. Medical College, Kanpur, Mudit Kumar| Department of pharmacy, G.S.V.M. Medical College, Kanpur, Ashish Kumar Gupta| Department of pharmacy, V.B.S.Purvanchal University, Jaunpur
Keywords
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