Study to evaluate the role of MRI in cases of primary malignant bone tumors

Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 3

Abstract

Background: Radiographs are the primary screening technique used for bone tumours and tumor-like lesions. When a lesion is indeterminate or shows signs of aggressiveness, magnetic resonance imaging (MRI) is indicated for further characterisation. Contrast-enhanced MRI (CEMRI) can reveal the most vascularised parts of the tumour and MRI guidance makes it possible to avoid biopsing necrotic areas. Objective: The purpose of this study was to evaluate the role of MRI in cases of primary malignant bone tumors and to determine the MRI characteristics of different primary malignant bone tumor and correlate and compare the imaging findings with surgical and gross pathological findings wherever possible. Materials and methods: We prospectively evaluated forty patients of suspected primary malignant skeletal neoplasms for two year period. Plain radiograph both antero-posterior and lateral projections were taken. Once the tumor was diagnosed on plain radiography, Magnetic Resonance Imaging (MRI) was performed in forty consecutive patients with malignant bone tumors. There were 21 males and 19 females. Results: Out of the 40 cases, thirteen were Osteosarcomas, eight were Ewing’s sarcomas, six were Chondrosarcomas, eight were Giant cell tumours, three were Chordomas, and two were multiple myelomas. Out of the thirty one cases operated, cortical involvement was seen in 27 cases and was absent in 4 cases. Thus sensitivity, specificity, positive predictive value and negative predictive value of MRI in detecting cortical involvement in our study were 96.2%, 100%, 100% and 80% respectively. Marrow involvement was seen in all cases on MRI and was confirmed by surgical and pathological findings in thirty one cases. Extra osseous soft tissue involvement was seen in 34 cases out of 40 cases. Soft tissue involvement was not seen 4 cases of GCT, two cases of Ewing’s sarcoma. Out of total forty cases, 12 cases showed joint involvement on MRI 32.5% cases demonstrated involvement of joint and 67.5% cases did not show joint involvement on MRI. The sensitivity was 100%, specificity 90.4%, positive predictive value 83.3% and negative predictive value 100%. Out of a total of forty cases, MRI showed neurovascular bundle involvement in four, so 10% cases demonstrated involvement of neurovascular bundle. The sensitivity in our study was 100%, specificity 96.2%, positive predictive value 100 % and negative predictive value was 96.2%. Conclusion: MRI is the modality of choice for determining local extent and tumour staging.

Authors and Affiliations

Nitishkumar Dhanajirao Yeslawath

Keywords

Related Articles

Assessment of awareness about HIV/AIDS in slum areas of Jodhpur city

Background: Human immunodeficiency virus (HIV) infection, the disease, whose mode of transmission is known and is largely preventable, but due to lack of knowledge and practices in general population causes its continuou...

Nasal Endoscopic Dacryocystorhinostomy – The Nizamabad experience

Chronic dacryocystitis results very often from obstruction to the nasolacrimal duct. It manifests as epiphora or watering of the eyes. The lacrimal sac gets expanded and also the wall of the sac gets thickened as a resul...

Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Staphylococcus aureus (VRSA) from a rural based tertiary care and teaching hospital in Vadodara district, Gujarat

Background: Staphylococci are ubiquitous being the normal inhabitants of the skin and mucous membranes and the most common cause of human infections all throughout the world, both the community acquired as well as nosoco...

A case report of HELLP syndrome

HELLP syndrome is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count. This case demonstrated the importance of rapid and early diagnosis and treatment of HELLP s...

Morphometric study on posterior papillary muscles of human tricuspid valve

Background: Aim of the present study was to observe the measurements of posterior papillary muscles present in tricuspid valve of human heart. Measurements of posterior papillary muscles in tricuspid valve gains utmost i...

Download PDF file
  • EP ID EP418310
  • DOI -
  • Views 121
  • Downloads 0

How To Cite

Nitishkumar Dhanajirao Yeslawath (2016). Study to evaluate the role of MRI in cases of primary malignant bone tumors. International Archives of Integrated Medicine, 3(3), 87-94. https://www.europub.co.uk/articles/-A-418310