Studying Cytokine Profile in Patients with Juvenile Rheumatoid Arthritis During Biological Therapy
Journal Title: Здоров`я дитини - Year 2014, Vol 5, Issue 56
Abstract
Application of biological preparations provides a possibility to decrease activity of inflammatory process аnd to achieve remission in patients with juvenile rheumatoid arthritis (JRA), who previously did not respond to traditional baseline therapy. Aim of the investigation: to improve monitoring of biological therapy effectiveness in patients with severe JRA by studying main cytokines level in blood serum against adalimumab and tocilizumab therapy. In Western-Ukrainian specialized children’s medical centre 105 patients with JRA were under follow-up during four years, biological therapy was used in 23 of them. Analysis of cytokine dynamics in 1, 3, 6 months after biological therapy initiation shows decrease in IL-6, sCD25 and sTNF-αR1 levels. IP-10 level during biological therapy remained increased. We also detected increased serum TNF-α level. Preserved increase in IL-6 level in 6 months after biological therapy initiation indicated its ineffectiveness. Changes in serum IL-6 and soluble receptors to cytokines sTNF-R1 and sCD25 can be used for evaluating effectiveness of biological therapy with adalimumab and tocilizumab in patients with JRA.
Authors and Affiliations
Ya. Ye. Boyko, V. P. Chernyshov, L. I. Omelchenko
Keywords
Related Articles
- EP ID EP316517
- DOI -
- Views 95
- Downloads 0
Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease
Background. Nonalcoholic fatty pancreas disease sis an excessive fat infiltration of the pancreas due to obesity in the absence of secondary steatosis. Nonalcoholic fatty liver disease is associated with progredient cour...
Place of Undifferentiated Connective Tissue Dysplasia in Childhood Pathology (Literature Review)
The article presents literature review on the problem of undifferentiated connective tissue dysplasia in children and formation on its background of congenital malformations of the urinary system. The etiological aspects...
The Wait is Over…
The paper presents a new pediatric problem: HIV-negative children, born to HIV-positive mothers, require observation and correction of immunity. The findings are confirmed by a clinical case.
Nosospecific features of redox processes in bronchial asthma and chronic obstructive pulmonary disease
The literature review presents current data on the specific features of oxidative stress, the functional activity of the antioxidant system and development of the inflammatory process in bronchial asthma and chronic obst...
Clinical and Diagnostic Features of Bronchial Asthma in Children on the Background of Latent Food Allergy
Based on clinical and paraclinical examination of 112 children with bronchial asthma, there were studied the features of its course against the background of food allergy. It was found that only a set of clinical and par...