Studying the influence of the natural zeolite tablets manufacturing technology on sorbtion kinetic of long-living 90Sr and 137Cs radionuclides and Pb2+ and Hg2+ heavy metals from water solution in vitro
Journal Title: ScienceRise: Pharmaceutical Science - Year 2018, Vol 0, Issue 2
Abstract
<p><strong>Aim:</strong> To study the influence of the technology on the adsorption activity of natural zeolite tablets (clinoptilolite) in relation to long-lived <sup>90</sup>Sr and <sup>137</sup>Cs radionuclides and Pb<sup>2+ </sup>and Hg<sup>2+</sup> heavy metals from an aqueous solution in vitro.</p><p><strong>Methods:</strong> Tablets were prepared by direct pressing and pressing with pre-wet granulation (a moisturizer - 7 % starch paste). Sorption capacity of enterosorbents was investigated by the method of static sorption at pH = 2–8 at a temperature of 37 °С. The concentration of lead in solutions was determined by atomic absorption spectroscopy at the atomic absorption spectrophotometer C-115 PCS. The concentration of mercury was determined by the method of flameless atomization with the help of the mercury device PR-115. The content of radionuclides was determined by the radioactivity of the samples using a radiometer α-β-automaton NRR-610 "Tesla".</p><p><strong>Results:</strong> Based on the results of the conducted studies, the adsorption activity of the model specimens of enterosorbents on the basis of natural zeolite in the form of tablets obtained by the technology of direct pressing and pressing with pre-wet granulation, was studied. It has been found that the sorption properties of samples relative to heavy metals and radionuclides depend to a greater extent on the acidity of the solution than on the technology of obtaining tablets. It was found that the process of ion exchange on experimental samples consists of two stages - fast and slow. This fact is explained by the adsorption of ions, primarily within the macro- and mesopor, on the material's surface, and the subsequent reduction of the velocity by diffusion of ions within the microporous space, and the last stage is limiting in the process of adsorption. Comparison of the obtained data on the sorption-selective properties of samples allowed to arrange the investigated ions in order of decreasing their interaction with sorbents Pb<sup>2+</sup>> Hg<sup>2+</sup>> <sup>137</sup>Cs> <sup>90</sup>Sr.</p><p><strong>Conclusions:</strong> It is proved that the technology of obtaining tablets does not significantly affect the activity of the drug in vitro. The results of experimental studies will be used in the further development of the composition and technology of tablets containing natural zeolite (clinoptilolite) as the main active ingredient</p>
Authors and Affiliations
Vasiliy Rybachuk, Olena Ruban, Alla Krasnopyorova, Galina Yuhno
Keywords
Related Articles
- EP ID EP526824
- DOI 10.15587/2519-4852.2018.128730
- Views 218
- Downloads 0
Determination of the optimal parameters and ionization products of riboxinum
<p>Currently, mass spectrometry is one of the most widely used rapid methods of analysis; it is used to determine the structure of both individual synthetic and natural organic compounds and their mixtures. One of the wa...
Исследование стабильности иринотекана при использовании различных методов активной загрузки липосом
<p>Рассмотрены механизмы активной инкапсуляции иринотекана в липосомы по технологиям «градиента рН» и технологии «градиента аммония».</p><p><strong>Цель работы:</strong> используя данные о механизме конверсии иринотекана...
Fatty acid composition of common bugle herb (Ajuga reptans L.)
<p> </p><p><strong>Aim.</strong> Identification and determination of the qualitative composition and quantitative content of fatty acids in the grass of Ajuga reptans.</p><p><strong>Methods of the research.</strong> The...
Development of mask-cream technology with herbal substances for the androgenic alopecia treatment
Aim. The aim of the study was to develop a rational technology of mask-cream containing Sabal palm extract and Sophora japonica tincture applied for prevention and tratment of androgenic alopecia. Methods. Pharmaco-tech...
Вивчення чинників, що впливають на якість підготовки фармацевтичних фахівців
<p><strong>Мета: </strong>вивчення чинників, які вливають на якість підготовки сучасних фармацевтичних фахівців для можливості нівелювання інерційності розвитку реформи вищої фармацевтичної освіти та підвищення ефективно...