Subclinical Hypothyroidism in type 2 diabetes mellitus patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
Introduction: Diabetes mellitus (DM) is the most common metabolic disease and its prevalence is increasing rapidly. Studies have reported that there is thyroid dysfunction in Type 2 Diabetes Mellitus patients. Subclinical hypothyroidism (SCH) is the most common in diabetes mellitus patients. The present study aims to evaluate the subclinical hypothyroidism in type 2 diabetes mellitus patients. Materials & methods: This, cross sectional case-control study, conducted in Department of Physiology in association with Department of Endocrinology, JNU Institute for Medical Sciences & Research Center, Jaipur. A total of 45 ambulatory type 2 diabetes mellitus patients were taken as cases and 45 healthy subjects served as controls. After taking aseptic precautions fasting venous blood samples were collected from the study subjects. Three ml of blood was collected in plain tubes and 2 ml of blood was collected in EDTA tubes. Serum was used for the estimation of fasting blood sugar (FBS) by using ERBA chemistry analyzer. FT3, FT4 and TSH by ELISA method, using mini VIDAS and EDTA sample is used for estimation of HbA1c by using BIORAD-D10. Data were expressed as mean ±SD. P value <0.05 is considered as statistically significant. Results: In the present study, FBS, HbA1c, TSH levels were significantly increased in type 2 diabetes mellitus patients compared with the controls. FT3 and FT4 levels were not significant. There is a non significant weak positive correlation between HbA1c and TSH. Conclusion: In the present study, plasma levels of TSH levels were significantly increased in T2DM patients compared to normals and FT3, FT4 levels were normal which suggests that there is a subclinical hypothyroidism in type 2 Diabetes Mellitus Patients.
Authors and Affiliations
Ajit Thakur, Dr. Suresh Nayak Basavanayak, Dr. Gayathri Lakshminarasappa, Dr. Jyoti Batra
Keywords
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