Synteza i aktywność biologiczna pochodnych 2,6-naftyrydyny
Journal Title: Wiadomości Chemiczne - Year 2012, Vol 66, Issue 3
Abstract
2,6-Naphthyridine is one of the six structural isomers of pyridopyridines. This review presents most of the literature data about natural and synthetic 2,6-naphthyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of 2,6-naphthyridine analogues. Compounds containing 2,6-naphthyridine moiety can be synthesized from different substrates. Most of them have been obtained by cyclocondensation of various pyridine derivatives. During the past twenty years the biological activity of 2,6-naphthyridines have been studied. Presented compounds exhibit anticancer [21, 41], antihypertension [10], and antidepression [25] activity. Some of them can be used in the treatment of heart diseases [22], appetite disturbance, and obsessive states [43, 44]. 2,6-Naphthyridine derivatives with different molecular targets, e.g. topoisomerase [41], SERT [27], and protein kinases [21, 22] inhibitors have also been reported. Many of the 2,6-naphthyridine analogues are histamine H3 [27] and serotonine 5-HT2 [42–44] receptor antagonists.
Authors and Affiliations
Anna Wójcicka, Edwin Wagner
Keywords
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