Synteza i aktywność biologiczna pochodnych pirolo[2,3-d]pirydazyny
Journal Title: Wiadomości Chemiczne - Year 2016, Vol 70, Issue 3
Abstract
Pyrrolo[2,3-d]pyridazines are one of the four structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridazine ring. This review presents most of the literature data about synthetic pyrrolo[2,3-d]pyridazine derivatives and their biological activity. These 5,6-diazaindole analogues were first synthesized by Fischer et. al. in 1928. Compounds containing the pyrrolo[2,3-d] pyridazine scaffold can be synthesized from different substrates, but the syntheses may be classified into two main categories: annulation of pyrrole ring on to pyridazine derivatives or annulation of pyridazine ring on to pyrrole derivatives. Pyrrolo[2,3-d]pyridazine derivatives have attracted considerable interest, owing to diverse biological activities. Most of them have been studied as antitumor and antiviral. Pyrrolo[2,3-d]pyridazines can also be used as acid pump antagonist.
Authors and Affiliations
Aleksandra Redzicka, Beata Tylińska
Keywords
Related Articles
- EP ID EP585004
- DOI -
- Views 150
- Downloads 0
Okruchy XXVI. O "Układzie Okresowym" Primo Levi'ego
brak
Inżynieria komórkowa w systemach lab-on-a-chip
Lab-on-a-chip systems are promising tools in the field of cell engineering. Microfluidic systems are integrated microlaboratories consisting of many microstructures such as microchannels and microchambers, which can be u...
Badania kulometryczne na Wydziale Chemii Uniwersytetu Warszawskiego
The coulometric studies carried out in the Department of Chemistry of the University of Warsaw have been described. In the first part of this brief review there were discussed papers in which coulometric titration was us...
Metody syntezy pochodnych organicznych zawierających wiązanie potrójne węgiel-węgiel
Compounds containing triple bonds are lately in the centre of interest of many research groups. This is mainly connected with their usefulness as substrates to obtain complex compounds with various applications in differ...
Metody chemicznej ligacji w syntezie peptydów i białek. Część 1
Proteins are biological macromolecules affecting very important functions in the body. They are involved in many biochemical processes. They can perform catalytic functions acting as enzymes. They also participate in the...