SYNTHESIS AND ANTHELMINTIC ACTIVITY OF 3-(2-HYDRAZINO BENZOTHIAZOLES)-SUBSTITUTED INDOLE-2-ONE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Benzothiazoles and Isatins have emerged as structurally novel anthelmintics. Therefore various 3-(2-hydrazino benzothiazoles)-substituted Indole-2-one, were synthesized by condensation of various 2-hydrazino benzothiazole, 2-hydrazino 1,4-thaizine and 2-acid hydrazide benzothiazoles with different substituted Indole -2,3-diones (Isatins). The structures of the synthesized compounds (A1-6)(B1-6)(C1-6) were characterized by FTIR, 1HNMR and elemental analysis. All the synthesized compounds were screened for anthelmintic activity by using Indian adult earthwarms (pheretima postuma). The compounds A4-5, B4, C4 have showed good paralytic time, compared to standard albendazole drug.
Authors and Affiliations
Suresh CH , Venkateshwara Rao, Jayaveera KN , Subudhi S. K.
Keywords
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