Synthesis and Anticonvulsant Activity (Chemo-Shock) of Some Potent Benzoxazole Semicarbazone Derivatives as GABA-Agonist
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 7
Abstract
Abstract:A series of novel semicarbazone derivatives (BS1-22) of (2E)-2-[2-(1, 3-benzoxazol-2-ylsulfanyl)-1-phenylethylidene] hydrazinecarboxamide have been prepared. The structural conformation of the newly synthesized compounds has been established by elemental analysis, spectral analysis and melting point studies. Compounds BS1, BS3, BS9, BS10, BS11, and BS21 have been subjected to anticonvulsant screening by chemo-shock models. In the series, compounds BS9, BS10, and BS11 showed most potent result while compounds BS1, BS3, and BS21 were showing moderate results than standard drug. Keywords: Benzoxazole, Semicarbazone, Chemo-shock, Anticonvulsant.
Authors and Affiliations
Bal Krishna Singh, Umesh Kumar Singh, Diptendu Goswami
Keywords
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