Synthesis and Biological Evaluation Of Some 2-Substituted Derivatives Of Benzimidazoles
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, a ntihistaminic, a ntimicrobial, anticancer, c ycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibitor activi ties. 2-alkyl benzimidazole and 2-aryl benzimidazoles were synthesized with different acids namely a cetic acid, o-c hlorobenzoic ac id, b enzoic ac id a nd cinnamic a cid. These were f urther treated with tosyl c hloride a nd benzoyl c hloride t o get Nsubstituted be nzimidazole de rivatives. These N-substituted be nzimidazoles wer e tested for antimicrobial ac tivity a gainst Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Some o f th e products exhibited interesting ac tivity wi th known s tandard drug at same concentration. The study was aimed to develop some benzimidazoles with antimicrobial activity.
Authors and Affiliations
S. K. Gupta , M. P. Khinchi , S S Pancholi , M K Gupta , Dilip Agrawal
Keywords
Related Articles
- EP ID EP102593
- DOI -
- Views 131
- Downloads 0
SPECTROPHOTOMETRIC METHODS FOR QUANTITATIVE ESTIMATION OF SPARFLOXACIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Two simple and sensitive Spectrophotometric methods [A and B] have been developed for the quantitative estimation ofSparfloxacin in bulk and Pharmaceutical dosage forms. Method-A was based on condensation of Sparfl...
Adherence T0 Drug Therapy In Psychiatric Patients
Adherence is very important issue in any drug therapy especially in psychiatric illnesses. Medicines do not work if not taken ,if taken in accordance with advice, provide maximum benefit in terms of positive clinical out...
Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on Wistar albino rats.
Calotropis gigantea Linn and Tridax procumbens Linn, are well documented medicinal plants distributed in Asia and Africa and are useful for many ailments. The anti-inflammatory activity of low dose of the aqueous e...
Physio- Phytochemical screening and Diuretic activity of leaves of Pavetta indica Linn
Pavetta indica Linn is used in the traditional medicine for many diseases.In the present study, the diuretic activity of Petroleum ether and Methanol extract of leaves of Pavetta indica was studied and the activity was...
VALIDATED RP-HPLC METHOD FOR FLUVASTATIN SODIUM IN BULK AND ITS DOSAGE FORM
A Simple, selective and rapid reverse-phase high Performance Liquid Chromatography (RP-HPLC) method for the analysis of fluvastatin sodium in bulk and in tablet dosage form has been developed and validated. The method wa...