SYNTHESIS AND BIOLOGICAL STUDIES OF CHERIMOLACYCLOPEPTIDE E AND ITS N- METHYLATED ANALOG  

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12

Abstract

The N-methyl derivative of Cherimolacyclopeptide E cyclo[Phe-(Dimethyl)Tyr-Pro-Gly-Leu-Gly] was synthesized using solution phase peptide synthesis. The synthesized compound was characterized by spectral data and was evaluated for anthelmintic and insecticidal activities. The compound exhibited potent anthelmintic activity as compared to the standard drug mebendazole. 

Authors and Affiliations

M Himaja , Rajan Siji , A. A Karigar, M. V Ramana

Keywords

Related Articles

STUDY ON THE EFFECTS OF VARIOUS DISINTEGRANTS ON AMOXICILLIN TRIHYDRATE DISPERSIBLE TABLETS 

The objective of this work was to develop a formulation of amoxicillin trihydrate dispersible tablets of 320mg in a low production value, using cheap amoxicillin trihydrate raw materials available in the market, with dir...

CRIMEAN CONGO HEMORRHAGIC FEVER - AN ARTICLE REVIEW  

Crimean–Congo hemorrhagic fever (CCHF) caused by negative-sense, single-stranded RNA virus in the genus Nairovirus, family Bunyaviridae. (CCHF) is a tick-borne infectious disease characterized by fever, malaise, headache...

COMPARISION BETWEEN THE EFFECT OF AQUEOUS AND METHANOLIC EXTRACTS OF HOLARRHENA ANTIDYSENTERICA BARK AGAINST EXPERIMENTALLY INDUCED INFLAMMATORY BOWEL DISEASE 

It has been demonstrated that Holarrhena antidysenterica Wall. (Apocynaceae) is useful as an adjunctive therapy for Inflammatory bowel disease (IBD). However, its effect on ulcerative colitis has not been investigated. I...

THE BIOPHARMACEUTICAL CLASSIFICATION SYSTEM (BCS): PRESENT STATUS AND FUTURE PROSPECTIVES  

The Biopharmaceutical classification system (BCS) was introduced By Amidon et al., (1995) as a method for classifying drug substances based on their dose/solubility ratio and intestinal permeability. It allows predicting...

THE NATURE'S GIFT TO MANKIND: NEEM  

Neem (Azadirachta indica) is popularly known as the miracle tree. It is known as ‘Nimba’ in India. The Sanskrit name of neem is ‘Arishtha’ meaning the reliever of the sickness. Neem also holds medicinal value. Each and e...

Download PDF file
  • EP ID EP160992
  • DOI -
  • Views 111
  • Downloads 0

How To Cite

M Himaja, Rajan Siji, A. A Karigar, M. V Ramana (2011). SYNTHESIS AND BIOLOGICAL STUDIES OF CHERIMOLACYCLOPEPTIDE E AND ITS N- METHYLATED ANALOG  . International Research Journal of Pharmacy (IRJP), 2(12), 270-273. https://www.europub.co.uk/articles/-A-160992