SYNTHESIS AND CHARACTERIZATION IN VITRO ANTIMICROBIAL AND CYTOTOXICITY TESTING OF OXALIC ACID-DERIVED CADMIUM CHELATING AGENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 7
Abstract
Objective: The aim of this study is to investigate the growth, structure, spectral, solubility and biological activity of sodium cadmium oxalate dehydrate (NaCdOx) and cadmium oxalate trihydrate (CdOx) crystals prepared by a single diffusion method in the silica gel medium.Methods: The present crystals were grown using single diffusion methods and tested for XRD, UV absorption (190 to 1100 mm) and solubility (distilled water at 20-29 °C) studies. The antimicrobial efficacy of the grown samples at various concentrations (25, 50, 75 and 100 μg/ml) was studied against Streptococcus, (G+Ve), Pseudomonas aeruginosa (G-Ve) and Candida albicans (antifungal). The cytotoxicity evolution was carried out against human cervical cancer cell line (HeLa) using MTT assays.Results: The existing single crystals were successfully grown by silica gel technique. The solubility of sodium cadmium oxalate dehydrate (NaCdOx) was moderately good in deionized warm water. The FTIR spectral studies confirmed the chelating bands of the present samples and UV spectra showed the better the optical conductivity of as-grown crystals. The complexes showed good antimicrobial activity against all tested microbial strains and they exhibited a decrease in cytotoxicity activity.Conclusion: The gel method was suitable to grow metal complexes of legend crystals. The modification of structural properties of cadmium oxalate trihydrate (CdOx) by sodium doping was much improved the solubility, anticancer, antimicrobial activity and polarization by the high optical conductivity of sodium cadmium oxalate dehydrate (NaCdOx) compound. Hence sodium cadmium oxalate dehydrate (NaCdOx) might be a candidate for biomedical applications.Â
Authors and Affiliations
Daisy Selasteen F, Alfred Cecil Raj S, Alagappa Moses A
Keywords
Related Articles
- EP ID EP566223
- DOI 10.22159/ijpps.2018v10i7.26034
- Views 74
- Downloads 0
ANTIMOTILITY AND ANTISECRETORY RELATED ANTIDIARRHOEAL ACTIVITY OF THE ABELMOSCHUS MOSCHATUS MEDIK IN EXPERIMENTAL ANIMAL MODELS
Objective: This study was intended to evaluate the anti-diarrhoeal potential of Abelmoschus moschatus Medik (A. moschatus Medik) seeds and the possible mechanism therein involved by using different experimental models in...
MILK WHEY PROTEINS MODULATE ENDOTOXEMIA-INDUCED HEPATOTOXICITY IN RATS
Objective: The therapeutic effects of whey protein isolate (WPI), alpha-lactalbumin (a-LA) and beta-lactoglobulin (β-LG) against endotoxemia-induced hepatotoxicity were investigated in female rats.Methods: Endotoxemia w...
COMPATIBILITY STUDIES OF RASAGILINE MESYLATE WITH SELECTED EXCIPIENTS FOR AN EFFECTIVE SOLID LIPID NANOPARTICLES FORMULATION
Objective: Compatibility study is an important element that should be performed at the early development stage of stable and effective solid dosage form.Methods: The compatibility studies of drug with different polymers...
VIRTUAL SCREENING STUDIES OF SEAWEED METABOLITES FOR PREDICTING POTENTIAL PPARγ AGONISTS
Objective: Peroxisome Proliferator-Activated Receptor-gamma (PPARγ) is a crucial nuclear hormone receptor, which modulates the transcriptional regulation of lipid and glucose homeostasis. It plays a crucial role in many...
DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF DULOXETINE
Objective: The aim of the present work was to develop and validate a simple UV spectroscopic method for the determination of duloxetine, which is a thiophene derivative and a selective neurotransmitter reuptake...