SYNTHESIS AND CHARACTERIZATION OF A NOVEL BONE GRAFT MATERIAL CONTAINING BIPHASIC CALCIUM PHOSPHATE AND CHITOSAN FORTIFIED WITH ALOE VERA
Journal Title: International Journal of Drug Regulatory Affairs - Year 2014, Vol 2, Issue 2
Abstract
The bone grafts were prepared using nanohydroxyapatite (nanoHAP) with the extracts of AV and mixed with beta tricalcium phosphate (βTCP) in a ratio of 60:40. The formed BCP was then conjugated with CH to form the bone graft. The Phytochemicals of AV imparts an anti-inflammatory and wound healing property to the bonegraft in addition to its osteoconductivity. The bone graft was subjected to various conventional characterization techniques like FTIR, XRD, SEM, UV spectrophotometric analysis, compression and tensile strength to reveal its chemical composition, surface morphology and mechanical strength. The UV spectrophotometric analysis and SEM images revealed the mineral deposition on the bone graft after immersing in SBF, thereby increasing its ossification property. FTIR and XRD revealed the presence of BCP with nano HAP crystals and Chitosan in the graft. Compression and tensile strength of the graft showed that the graft can be used in non–load bearing areas. In this study, a bone graft was synthesized using a novel technique of introducing the extracts of AV in the graft along with BCP and CH. The results revealed that the bone graft can be used as an Osteoconductive material for various biomedical applications.
Authors and Affiliations
Srividya S, Sastry T. P. , Jeevitha D, Samiksha N
Keywords
Related Articles
- EP ID EP349809
- DOI 10.22270/ijdra.v2i2.134
- Views 111
- Downloads 0
FORMULATION AND EVALUATION OF SOLID DISPERSION OF TADALAFIL
Tadalafil is used for the treatment of the erectile dysfunction (ED) and pulmonary arterial hypertension. It is having low aqueous solubility thus it shows poor bioavailability of about 28% by after oral administration....
INSIDE STORY FOR REVIEW OF AN ABBREVIATED NEW DRUG APPLICATION
ANDA constitutes an important submission for marketing authorization of generic drugs. The FDA has recently mandated an electronic submission in the form of eCTD for the same. ANDA application is quite complex with respe...
Overview of current Regulations governing Medical Devices
Medical Device (MD) is one of the fastest growing sector and so are the associated regulations. From lack of even policies and guidelines to stringent MD legislations in others, the requirements vary across countries. Un...
SELF-MEDICATION IN RELATION TO HEALTH LOCUS OF CONTROL
Present study was conducted to examine the association of self- medication and health locus of control. It was also intended to know the health problems for which people do self – medication and the medicines which are m...
REGULATORY STRATEGY FOR REGISTRATION OF COMBINATION PRODUCTS TO US-FDA
In pharmaceutical industry all the healthcare products are categorized into Drugs, Devices, and biologics and they are regulated by their respective departments of the regulatory authorities. Due to more and more develop...