SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONE DERIVATIVES FOR ANTIDIABETIC ACTIVITY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 5
Abstract
The aim of study was to synthesize a new series of thiazolidinedione’s. Thiazolidinedione’s or glitziness forms a significant class of drugs which exhibit biological activities ranging from antidiabetic, anti-inflammatory, antibacterial, antifungal, antiviral and anticancer. In the present study reported a systematic synthesis of thiazolidinedione analogues. A new series of 2, 4-thiazolidinedione based derivatives have been synthesized by the condensation of various substituted phenoxy benzene amines and 4’-chlorosulphonyl 5-benzylidene-2, 4-thiazolidinedione. The structure of these compounds were established by IR and 1H NMR. These new compounds (F1 – F7) were evaluated for their antidiabetic activity on albino rats. Most of the compounds showed significant antidiabetic activity when compared with the standard drug metformin.
Authors and Affiliations
Swapna D, Sivagami B, Manasa K, Rajita G , Alagarsamy V
Keywords
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- EP ID EP123129
- DOI 10.7897/2230-8407.07544
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