Synthesis and Evaluation of Some Novel N, NDialkylaminoalkoxy-2-Oxo-Indole-3-Ylidene Benzohydrazides as Anticonvulsant Agents
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
A series of N,N-dialkylaminoalkoxy-2-Oxo-indole-3-ylideneBenzohydrazides were synthesized by using the well designed synthetic route and the purity of the compounds were assessed by TLC, and characterized by FT-IR, NMR spectral data. The anti-convulsant activities of the synthesized compounds were evaluated against MES and PTZ induced seizure models in mice. All the test compounds were administered at doses of 50mg/kg body weight orally for MES method. The stimulus parameters in mice were 50mA in a pulse of 60Hz for 200ms. Intraperitonially for a PTZ method from the series of compounds it was noted that compound N,N-dimethylaminoPropoxy-2-Oxo-5-methyl-3-ylidenebenzo hydrazides(VIIb) protected more than 80% of the mice against MES and PTZ induced seizures compound VIId, VIIa, VIIe were found to be next in the order of reducing the duration of convulsions in both MES and PTZ methods. Molecular docking studies were also carried out by using windows 2007 using Moe 2008.10 version. The 5HT2c mouse receptor was retrieved from the protein data bank and used as target receptor was retrieved from the protein data bank.
Authors and Affiliations
Sravanthi Madhira, Kiranmai Mandava, Sarangapani Manda, Sai Prasanna R a ,, Vijayalaxmi Ta
Keywords
Related Articles
- EP ID EP388562
- DOI 10.9790/3008-1202028493
- Views 94
- Downloads 0
Antimicrobial and Phytochemical Screening of Seaweeds: Enteromorpha intestinalis and Ulva lactuca Collected from Indian Sunderbans Delta Region
The aim of this study was to evaluate the antimicrobial activities of two green seaweeds: Enteromorpha intestinalis and Ulva lactuca collected from the Matla river of Indian Sunderbans Delta. Both seaweeds showed antibac...
Isolation and Partial Characterisation of Bacteriocin Produced By Lactobacillus Fermentum
The present study was confined to the velar estuary in Cuddalore District, Tamil Nadu.Water samples were collected to isolate the bacteria. The collected samples were plated (MRS agar), incubated and the Bacterial coloni...
Enumeration of Anaerobic Bacteria from Marketed Table Grape to Determine the Health Hazard in Urban Areas of Jessore, Bangladesh
This study was conducted to identify contaminants in marketed white table grape for avoiding health hazard. White table grape samples were collected from Jessore, Bangladesh. The samples were inoculated into Nutrient Aga...
Evaluation Of Synergistic Effects Of Gongronema Latifolium And Piper Guineense Ethanol Extracts On Selected Biochemical Indices In Ethanol Exposed Wistar Rats
Combination therapy has been identified as a promising strategy to improve disease management. This work was designed to estimate the synergistic effects of Gongronema latifolium and Piper guineense in selected biochemic...
Isolation and Identification of therapeutic compounds from Moringa oleifera and its antimicrobial activity
Moringa oleifera, is commonly known as ‘drumstick tree’ or ‘horseradish tree’. Every part of the plant has high nutritive value. In this study the leaf extracts of Moringa oleifera was prepared using 7 different solvents...