Synthesis and Evaluation of Some Novel N, NDialkylaminoalkoxy-2-Oxo-Indole-3-Ylidene Benzohydrazides as Anticonvulsant Agents
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
A series of N,N-dialkylaminoalkoxy-2-Oxo-indole-3-ylideneBenzohydrazides were synthesized by using the well designed synthetic route and the purity of the compounds were assessed by TLC, and characterized by FT-IR, NMR spectral data. The anti-convulsant activities of the synthesized compounds were evaluated against MES and PTZ induced seizure models in mice. All the test compounds were administered at doses of 50mg/kg body weight orally for MES method. The stimulus parameters in mice were 50mA in a pulse of 60Hz for 200ms. Intraperitonially for a PTZ method from the series of compounds it was noted that compound N,N-dimethylaminoPropoxy-2-Oxo-5-methyl-3-ylidenebenzo hydrazides(VIIb) protected more than 80% of the mice against MES and PTZ induced seizures compound VIId, VIIa, VIIe were found to be next in the order of reducing the duration of convulsions in both MES and PTZ methods. Molecular docking studies were also carried out by using windows 2007 using Moe 2008.10 version. The 5HT2c mouse receptor was retrieved from the protein data bank and used as target receptor was retrieved from the protein data bank.
Authors and Affiliations
Sravanthi Madhira, Kiranmai Mandava, Sarangapani Manda, Sai Prasanna R a ,, Vijayalaxmi Ta
Keywords
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- EP ID EP388562
- DOI 10.9790/3008-1202028493
- Views 94
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