Synthesis and In vitro Antimicrobial Properties of Some New 4-(2-Benzoxy-3-ethoxy)-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol- 5-one Derivatives
Journal Title: International Research Journal of Pure and Applied Chemistry - Year 2017, Vol 15, Issue 2
Abstract
Aims: The present study involved the synthesis of heterocycylic Schiff bases and their biological activity. Study Design: Synthesizing some new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives and determining their chemical structure via IR and NMR spectroscopy. The synthesized compounds were analyzed for their in vitro potential antimicrobial and antioxidant activities. Place and Duration of Study: Department of Chemistry, Kafkas University, Kars, Turkey. Between September 2010 to September 2012. Methodology: Nine new 3-alkyl(aryl)-4-(2-benzoxy-3-ethoxy-benzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 2-benzoxy-3-ethoxy-benzaldehyde (2) which had also been synthesized by the reactions of 3-ethoxysalicylaldehyde with benzoyl chloride by using triethylamine. Results: Schiff bases were synthesized and their structures were determined with spectral methods. Antimicrobial and antioxidant evaluation were carried out, presented and discussed. Conclusion: Synthesis and structural determination of the new 3-alkyl(aryl)-4-(2-benzoxy-3-ethoxy-benzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) was successful. Considering both the antimicrobial and the antioxidant evaluation, compound 3c exhibited moderate effect.
Authors and Affiliations
Faruk Kardaş, Özlem Gürsoy-Kol, Murat Beytur, Muzaffer Alkan, Haydar Yüksek
Keywords
Related Articles
- EP ID EP321311
- DOI 10.9734/IRJPAC/2017/37845
- Views 82
- Downloads 0
Photocatalytic Degradation of Carbon Monoxide (CO) Using Bi2O3 Modified TiO2 Photocatalyst
TiO2 modified Bi2O3 nanoheterojunction was prepared using maleic acid as an organic linker. TiO2 phatocatalyst cannot perform photocatalytic reaction in the visible region. It only can work in the UV light region because...
Adsorption of 2, 4 Dichlorophenoxyacetic Acid on Different Types of Activated Carbons Based Date Palm Pits: Kinetic and Thermodynamic Studies
The removal of 2,4-dichlorophenoxyacetic acid (2,4-D) from waste water was studied by three activated carbon samples (AP21, AZ21 and AN13) prepared from date palm pits (DP) as a precursor and phosphoric acid, zinc chlori...
A Comparative Study of Two Different Media Effect on the Electropolymerization of 2-(9-ethylcarbazol-3-yliminomethyl)phenol by Cyclic Voltammetry, Impedance Spectroscopy, XPS, UV-visible Measurements and DFT Calculation
A carbazole-based monomer, 2-(9-ethylcarbazol-3-yliminomethyl)phenol (SIC), was first synthesized and characterized. It was afterward polymerized by potentiostatic methods. Oxidative polymerization of SIC was carried out...
Development of Novel Herbicidal Ionic Liquids
Aims: The present study involved the synthesis of small carboxylic acid based ionic liquids as potential herbicides. Study Design: Synthesized ionic liquids. Place and Duration of Study: Organic Synthesis Laboratory, Dep...
Synthesis Antioxidant and Antibacterial Studies on 2-(2-arylamino-4-phenylthiazol-5-yl)benzofuran Derivatives
A series of 2-(2-arylamino-4-phenylthiazol-5-yl)benzofurans derivatives were synthesized from 1-aryl-3-(N-phenylbenzimidoyl)thiourea and 2-(2-bromoacetyl)benzofuran in the presence of triethylamine. Their structure was...