SYNTHESIS AND REACTIONS OF SOME NEW MORPHOLINYLPYRROLYL TETRAHYDROTHIENO[2,3-c] ISOQUINOLINE
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 10, Issue 3
Abstract
Hydrazinolysis of ethyl-5-morpholin-4-yl-1-(1H-pyrrol-1-yl)-6,7,8,9-tetrahydrothieno[2,3-c]iso- quinoline-2-carboxylate afforded the corresponding carbo- hydrazide which upon condensation with aromatic aldehydes, acetyl acetone and/ or carbon disulfide gave N- arylidinecarbohydrazide, dimethylpyrazolyl methanone, [1,3,4]oxadiazole-2-thiol and its ethyl ester derivatives respectively. Diazotization of the carbohydrazide with nitrous acid afforded the corresponding carboazide which was used for synthesis of carbamates and substituted carboxamides. Boiling of the carboazide in dry xylene afforded the pyrazinone compound which was used for synthesis of other heterocycles containing pyrrolopyrazinothinoisoquinoline moeity.
Authors and Affiliations
Remon Melad Zaki, Adel M. Kamal El-Dean, Shaban M. Radwan
Keywords
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- EP ID EP652769
- DOI 10.24297/jac.v10i3.6659
- Views 126
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