SYNTHESIS, CHARACTERISATION AND ANTICANCER ACTIVITY OF SCHIFF BASE DERIVATIVES OF 5-(2-PHENOXYPYRIDIN-3-YL)-1, 3, 4-THIADIAZOL-2-AMINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
Schiff Bases of 5-(2-phenoxypyridin-3-yl)-1, 3, 4-thiadiazol-2-aminederivatives 6(a-h) have been synthesized with different aromatic aldehyde and tested for in vitro anticancer activity; the 1, 3, 4-thiadiazole derivatives were prepared by the reaction ofthiosemicarbazide, phosphorousoxychloride and aromatic acids. The synthesized final Schiff base compounds were purified by column-chromatography and the structures of the titled Schiff bases were elucidated by IR, 1H NMR and LCMS spectral measurements. Three different cell lines namely Hela, Hep-G2 and MCF7 are used for the present study. The compounds tested were, in most of cases shows cytotoxic effect but, only one compound showed good activity on breast carcinoma cell line having IC50 = 2.28 μg/ mL.
Authors and Affiliations
Vinayak Adimule , Sudha Medapa , Prakash Rao , Lalita Kumar
Keywords
Related Articles
- EP ID EP93841
- DOI 10.7897/2230-8407.041214
- Views 138
- Downloads 0
ORAL SUSTAINED RELEASE DRUG DELIVERY SYSTEM: AN OVERVIEW
In the recent years, focus on the development of oral controlled release drug delivery systems has increased. Oral ingestion has been the most convenient and commonly employed route of drug delivery. Indeed, for sustaine...
ALOE VERA: A REVIEW OF ITS CLINICAL EFFECTIVENESS
Aloe vera has been used for over five thousand years. Throughout history, it has been considered a magical plant, almost a panacea, capable of remedying many of mankind’s ailments. It is only in the last 20 years, after...
A RECENT UPDATE OF BOTANICALS FOR WOUND HEALING ACTIVITY
Healing of wounds, whether from accidental injury or surgical intervention, involves the activity of an intricate network of blood cells, tissue types, cytokines, and growth factors. This results in increased cellular ac...
CLINICAL EVALUATION OF ‘SUSPEND’ TRIAL WITH HERBAL PREPARATION AND TAMSULOSIN: A MEDICAL EXPULSIVE THERAPY FOR UROLITHIASIS
Lithiasis occurs in various forms and at various sites in the body and the most common site is urinary tract. Urinary stones are one of the major problems and an important cause of morbidity and end stage renal failure i...
A COMPARATIVE CLINICAL TRIAL OF AMALAKI AND MADHUYASHTI CHOORNA IN AMLAPITTA
Amlapitta can be a result of inappropriate dietary regimen or stress. It is a problem which when left unattended to, results in peptic ulcer and other complications. It is quite a simple problem when it begins, but it ca...