SYNTHESIS, CHARACTERIZATION, AND ANTHELMINTIC ACTIVITY OF NOVEL BENZOTHIAZOLE DERIVATIVES CONTAINING INDOLE MOIETIES
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: The objective of this study was to synthesize and evaluate the anthelmintic activity (AA) of novel benzothiazole derivatives containing indole moieties (BDIM). Methods: The present works which involve the substituted isatin Schiff bases undergo acetylating and reacting with 2-aminobenzothiazole to give novel BDIM. Results: All the newly synthesized molecules (5a-5o) were characterized by Fourier-transform infrared spectroscopy, H_nuclear magnetic resonance, and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their AA using an Indian earthworm (Pheretima posthuma), and albendazole was used as standard drug. Conclusion: The synthesized compound 5f, 5n, and 5o showed good AA, whereas others exhibited significant activities.
Authors and Affiliations
ALETI RAJAREDDY, SRINIVAS MURTHY M
Keywords
Related Articles
- EP ID EP603880
- DOI -
- Views 112
- Downloads 0
CURRENT DEVELOPMENTS IN TRANSPORT MEDIA FOR AVULSED TEETH: AN UPDATE
Dental avulsion is one of the common types of trauma that results in the complete displacement of tooth from the alveolar socket. Although the ideal treatment would be the immediate reimplantation of the tooth at the sit...
WATER SOURCE AS THE MAIN RISK FACTOR OF SOIL-TRANSMITTED HELMINTHS INFECTION ON PRIMARY SCHOOL STUDENTS IN ANTIGA VILLAGE, BALI
Objective: This study aims to find out the main risk factor of soil-transmitted helminths (STH) infection, so the results of this study can be used to determine the right steps in STH education and eradication. Methods:...
PHARMACOLOGICAL POTENTIALS OF PYRIMIDINE DERIVATIVE: A REVIEW
The chemistry of pyrimidine derivatives plays an important role in the field of drugs, agriculture chemicals and many biological processes. The chemistry of pyrimidine is a provoking field. In recent decades, a large num...
ROLE OF VITAMIN C AND VITAMIN E ON HYPERTENSION
Objective: Both Vitamin C and Vitamin E supplementation were associated with reduction in blood pressure (BP) in observational studies, although, results of clinical trials are inconsistent. The objective of our study is...
DETERMINATION OF NUTRITIVE VALUE AND MINERAL ELEMENTS OF FICUS BENGHALENSIS LINN. SEED
 ABSTRACTObjectives: This study was undertaken to assess the nutritive value and mineral contents of Ficus benghalensis seed locally prescribed as a diet forstomach ulcer.Methods: The nutrients were analyzed by using di...