SYNTHESIS, CHARACTERIZATION, AND ANTI-BACTERIAL ASSESSMENT OF NEW GATIFLOXACIN ANALOGUES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 2
Abstract
New gatifloxacin analogues were synthesized by coupling with different sulfonamide derivatives (sulfanilamide, and sulfacetamide), using chloroacetyl chloride linker, in order to increase the bulkiness at position 7 of the flouroquinolone by that reduce the efflux of the antibiotic from the bacterial cells and bacterial resistance will reduced consequently. The chemical structures of the synthesized compounds were confirmed and characterized using FT-IR spectroscopy, and elemental microanalysis, in addition to some physicochemical properties as melting points and Rf values. The antibacterial study was showed comparable effect of the prepared compounds with Gatifloxacin. The largest inhibition zone was observed with compound IIa against bacteria Bacillus cereus and the lowest inhibition zone was observed with compound IIa against bacteria Proteus mirabilis.
Authors and Affiliations
Noor H. Nasser
Keywords
Related Articles
- EP ID EP620693
- DOI -
- Views 149
- Downloads 0
EVALUATION OF KALLISTATIN AS A BIOMARKER IN CHRONIC HEPATITIS C PATIENTS
Early outcome prediction after hepatitis C viral infections has a great interest. This study aims to evaluate kallistatin in the prediction of liver fibrosis in chronic hepatitis C Egyptian patients. This study included...
A COMPARATIVE STUDY OF THE EFFECT OF VARIOUS KINETIC PARAMETERS ONSYMMETRIC REDUCTION OF KETONES USING TETRABUTYLAMMONIUM FLUORIDE AND POLYMETHYLHYDROSILOXANE
The present work is aimed mainly to investigate and find optimal conditions by changing various kinetic parameters on reaction conversion such as duration of reaction, effect of temperature, and solvent. THFwas found to...
KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS BLOOD DONATION AMONG MEDICAL STUDENTS IN TAIF UNIVERSITY
Background: Blood transfusion saves lives; the most imperative factor, which need blood, is road traffic accident on emergency department, the world health assembly (WHA 63) urges all the member states to develop nationa...
STUDY OF SOME BIOCHIMETICAL PARAMETERS IN LENTIL GENOTYPES
This article is about comparative study of lentil variety samples (Arzu, F2010-19, F2010-91, F2010-95, F2010-97, F2010-101, F2011-13, F2011-14, F2011-17, F2011-18, F2011-19, F2011-35, F2011-37, F2011-41, F2011-42, F2011-...
EFFECT OF BODY MASS INDEX AND WAIST CIRCUMFERENCE ON BLOOD PRESSURE IN ADULTS
Background: Hypertension in adolescence is increasing with obesity epidemic. Body mass index (BMI) and waist circumference (WC) are used to assess obesity. WC can be suggested to be a better predictor of high blood press...