Synthesis, Characterization and Antimicrobial Activity of Some Novel 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Derivatives
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2015, Vol 11, Issue 6
Abstract
The present research work deals with synthesize a series of various substituted benzothiazole containing 6-amino- 4-(substituted aryl)- tetrahydropyrano[2,3-c]pyrazole-5-carbonitrilic by reacting 2-mercaptobenzothiazole with hydrazine hydrate to synthesize hydrazine derivatives of benzothiazole (1), which then reacted with β- keto ester to develop pyrazole derivative (2), and then finally reacted with malononitrile and different aromatic aldehydes to obtain the final compounds (3a-3f). The structures of the intermediates and final compounds are assigned by using FTIR and 1H-NMR. The final compounds were screened for their antibacterial activity against four tested bacteria as G+ and G- using a well diffusion method. The results of antibacterial activity exhibited that the species Klebsiella pneumonia was the most effected types, while Pseudomonas aeruginosa was least the effected in general.Â
Authors and Affiliations
Monther Mahdi
Keywords
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- EP ID EP652855
- DOI 10.24297/jac.v11i6.851
- Views 153
- Downloads 0
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