SYNTHESIS OF DESGLYMIDODRINE FROM MIDODRINE BY CONVENTIONAL AMIDE HYDROLYSIS METHOD
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 2
Abstract
Objective: The term prodrug involves chemically modifying inert compound which upon administration releases the active parent drug to elicit its pharmacological response within the body. Acting as a α-adrenergic agonist, desglymidodrine an active metabolite of amide prodrug midodrine is used for the treatment of essential and orthostatic hypotension. In the present study synthesis of desglymidodrine from midodrine was reported.Methods: The synthesis was done by the conventional amide hydrolysis method.Results: A novel synthesis of desglymidodrine was successfully achieved and spectrally elucidated by infrared spectroscopy (IR), 1H, 13C nuclear magnetic resonance (NMR) and mass analysis.Conclusion: The acquired results were found to be accurate, the synthetic route appeared to be simple, cost-effective and time efficient. Hence the synthesized desglymidodrine can be as a reference standard for the estimation of the same.
Authors and Affiliations
S. T. Narenderan, Srikanth Jupudi, P. Vanaja, S. N. Meyyanathan
Keywords
Related Articles
- EP ID EP575386
- DOI 10.22159/ijpps.2018v10i2.23251
- Views 96
- Downloads 0
HOMOLOGY MODELING OF SHORT CHAIN NEUROTOXINS: AN INITIATION TOWARDS UNDERSTANDING THEIR FUNCTIONAL INFERENCE
Objectives: Various types of venoms are being produced by different toxic species which make mild or severe damage to the biological system of target species. The main objective is to disseminate structural information i...
QUANTITATIVE ANALYSIS OF Α-MANGOSTIN IN MANGOSTEEN (GARCINIA MANGOSTANA L.) PERICARP EXTRACT FROM FOUR DISTRICT OF WEST JAVA BY HPLC METHOD
Objective: The objective of this study was to determine the validity of analytical methods of α-mangostin using HPLC with UV detector and acidic methanol as mobile phase. Then, compare the level of α-mangostin and qual...
ANTI-QUORUM SENSING ACTIVITY OF SOME COMMONLY USED TRADITIONAL INDIAN SPICES
Objective: To investigate the total phenolic and flavonoids contents and study the anti-quorum sensing activity of Indian spices.Methods: The methanolic extracts of eight Indian spices were evaluated for phytochemicals a...
A STUDY ON HYPERPHOSPHATEMIA AND EFFECT OF SEVELAMER ON CARDIAC ENZYME LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS
Objective: Chronic Kidney Disease (CKD) is characterized by progressive loss of kidney function over a period of time. Sevelamer hydrochloride is a phosphate binding agent used to control serum phosphate levels in End St...
SMEDDS TABLET: COMPATABILITY OF SOLID SMEDDS USING VARIOUS PHARMACEUTICAL TABLET EXCIPIENTS
Objective: There are many successful products on the market which are the culmination of the self-micro-emulsification lipid technology applications. Despite the importance of lipid-based formulations, these systems have...