SYNTHESIS OF NANOSTRUCTURES ON THE BASIS OF DIAZACROWN ETHER AND MAGNETITE NANOPARTICLES LOADED BY CEPHALOSPORIN ANTIBIOTICS
Journal Title: Azerbaijan Chemical Journal - Year 2018, Vol 0, Issue 3
Abstract
Synthesis of hydroxyl containing azacrown macrocycles (MC) that is able to mimic the properties of natural siderophores has been perfomed. On the basis of synthesized MC the supramolecular ensembles with magnetite nanoparticles, loaded by cephalosporin antibiotics were prepared. The synthesized MC was investigated by NMR, mass-, FTIR spectroscopy methods. The morphology of prepared nanoensembles was analyzed by scanning electron microscopy SEM, FTIR, X-ray diffraction XRD analysis methods. The quantitative analysis of nanostructures was made by atom absorbance spectroscopy (AAS) as well as on the basis of Lambert–Beer law by UV spectroscopy method. Prepared nanostructures were tested on gramnegative Escherichia Coli and gram -positive Staphylococcus aureus, having multi drug resistance propertie it has been found that the nanostructures significantly increase the antimicrobial effect of cephalsporins and decrease their minimum inhibitory concentration (MIC)
Authors and Affiliations
U. A. Hasanova, L. Z. Vezirova, Z. O. Gakhramanova
Keywords
Related Articles
- EP ID EP492345
- DOI 10.32737/0005-2531-2018-3-66-73
- Views 147
- Downloads 0
NEW METAL-FREE CATALYSTS FOR THE SELECTIVE HYDROGENATION OF MULTIBLE BONDS İN AROMATİC HYDROCARBONS BASED ON GRAPHITIC CARBON NITRIDES
There has been demonstrated for the first time that polymeric carbon nitrides with graphitic structure can be successfully used as a metal-free catalyst for the selective hydrogenation of multiple bonds of aromatic compo...
CHARACTER OF INTERACTION AND GLASS FORMATION IN THE AsSe–NdAs2Se4 SYSTEM
The character of the chemical interaction and glass formation in the AsSe–NdAs2Se4 system was studied by physico-chemical analysis methods (DTA, RFA, MSA), as well as by measuring the microhardness and density, and a sta...
STRONTIUM CONTAINING SULPHONATES ON THE BASIS OF ALKYLPHENOL AS MULTIFUNCTIONAL ADDITIVES FOR LUBRICATING OILS
Based on sulphomethylated alkyl(C25–C30)phenol new modifications of sulphonate type additives-strontium hydroxyalkylbenzylsulphonate have been synthesized and studied. Developed base and medium alkaline sulphonates are c...
SYNTHESIS AND CRYSTAL STRUCTURE OF THE MnGaInSe4 COMPOUND
The compound MnGaInSe4 was synthesized from the ternary compounds MnGa2Se4 and MnIn2Se4 by melting in conditions of vacuum. Its crystalline structure has been made precise on the basis of powder diffraction data by the R...
PHASEFORMATION IN THE SYSTEM InAs2S3Se–InAs2Se3S AND PROPERTIES OF OBTAINED PHASES
Compound InAs2S2Se2 was found during studying the system InAs2S3Se–InAs2Se3S. It was established that the compound InAs2S2Se2 melts congruently at 615 K. crystallizes in tetragonal syngony with lattice parameters: а=9.2...