Teoria serotoninowa a tętnicze nadciśnienie płucne
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Pulmonary arterial hypertension (PAH) is a progressive, complex disease leading to the right ventricular failure and premature death. PAH is characterized by increased pulmonary arterial pressure, increased vascular resistance, pulmonary vascular remodeling and endothelial dysfunction. Pathomechanism of this disease is still unknown. It has been suggested, that endothelial dysfunction is caused by unbalance between vasodilators and vasoconstrictors e.g. serotonin (5-HT). Previously, serotonin hypothesis was linked to the anorexigens, derivatives of fenfluramine, which are serotonin transporter (SERT) substrates. Nowadays, it has been proved that all elements of serotonergic system within pulmonary circulation participate in the developement of PAH. The tryptophan hydroxylase 1 (Tph-1) catalyses synthesis of 5-HT from tryptophan in the pulmonary arterial endothelial cells. 5-HT mediates contraction of pulmonary vessels via 5-HT1B and 5-HT2A receptors. 5-HT is also transported into pulmonary arterial smooth muscle cells via SERT and through activation of reactive oxygen species andRho-kinase may contribute to contraction or/and, via stimulation of transcription factors,lead to proliferation and remodelling. There is also increasing number of evidence about functionalinteraction between 5-HT1B receptor and SERT in modulation of vasoconstriction andproliferation in pulmonary arteries. This review discusses the role of 5-HT in the developmentof PAH and highlights possible therapeutic targets within serotonergic system.
Authors and Affiliations
Monika Kloza, Marta Baranowska-Kuczko, Anna Pędzińska-Betiuk, Konrad Jackowski, Hanna Kozłowska
Keywords
Related Articles
- EP ID EP67404
- DOI -
- Views 190
- Downloads 0
Glikowana albumina jako wskaźnik glikemii w cukrzycy i jej naczyniowych powikłaniach
Efektywna kontrola glikemii jest bardzo istotna w zapobieganiu powstawania i pogłębianiu się chronicznych powikłań u chorych na cukrzycę. Wiadomo, że u tych chorych w stosunku do ludzi bez cukrzycy wzrasta stężenie gliko...
Dietary fibre as an important constituent of the diet
The intake of fibre in the diet of a child or an adult, through various foods (such as wholegrain foods, nuts, fruits and vegetables), plays an important role in reducing the risk and lowering the incidence of numerous d...
Immunostimulatory properties of mistletoe extracts and their application in oncology
For a long time cancer immunotherapy was overshadowed by chemotherapy and radiotherapy. Recently, “Science”, one of the world’s top scientific journals, named the stimulation of the body’s own immune system to fight canc...
Proces dyfuzji prostej i ułatwionej długołańcuchowych kwasów tłuszczowych w patogenezie niealkoholowej stłuszczeniowej choroby wątroby
Niealkoholową stłuszczeniową chorobę wątroby (NAFLD) definiuje się jako nadmierną akumulację lipidów w hepatocytach, przekraczającą 5% ich objętości, u osób nienadużywających alkoholu. Współistnieje również z innymi zabu...
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction
Introduction: The subject of the study compare the influences of YC-1 guanylyl cyclase activator with ODQ guanylyl cyclase inhibitor on the tracheal smooth muscle contraction induced by carbachol. The study specified the...