The activity of metalloproteinases in the wall of abdominal aortic aneurysm
Journal Title: Medical Science Pulse - Year 2012, Vol 6, Issue 1
Abstract
The abdominal aortic aneurysm (AAA) constitute one of the main reasons for performing a vascular surgery. The metalloproteinases play an important role in the process of the aorta wall destruction and the aneurysm formation. The matrix metalloproteinases posses the ability to digest collagen, elastin, fibronectin and laminin. The increased activity of the matrix metalloproteinases causes the destruction of the extracellular matrix. In ceonsequence of the blood pressure on the damage wall of the abdominal aorta, it becomes dilated and the formation of the aneurysm occurs. In a series of experimental and clinical works an increased expression of genes for matrix metalloproteinases in the wall of abdomanl aortic aneurysms has been demonstrated. These results are used to compare with the results of metalloproteinase gene expression in other tissues or the healthy aorta. the precise knowledge of the role of MMPs in the pathogenesis of abdominal aortic aneurysms can be used in the prevention and treatment of aortic aneurysms.
Authors and Affiliations
Jan Skóra, Artur Pupka, Piotr Barć, Tomasz Dawiskiba
Keywords
Related Articles
- EP ID EP69071
- DOI -
- Views 223
- Downloads 0
O odpowiedzialnych badaniach i innowacjach – stare pojęcie w nowych szatach
Szybki rozwój nauki i technologii często budzi kontrowersje. Liczne przykłady badań, które zostały zakwestionowane lub odrzucone przez opinię publiczną pokazały dobitnie, że obawy społeczeństw nie powinny być ani ignorow...
Causes and efects of cave accidents in the area of Kraków-Częstochowa upland
Background: Mountain’s caves should be characterized by a set of unique rules and those who comply with them may be rewarded with the opportunity to experience memorable, worth cherishing moments. There are plenty of thr...
Assessment of the influence of ischemic compression and clavitherapy on compression pain threshold measured on the lumbar spine rectifier muscle
Background. The British physician, Balfour, at the beginning of the nineteenth century was one of the first to describe thickened nodules and bumps in tissue, which could be painful under pressure. This pressure often al...
Sposób żywienia i stan odżywienia dziewcząt wyczynowo uprawiających piłkę nożną
Wstęp: Piłka nożna kobiet w ostatnich latach stają się coraz bardziej popularna. Prawidłowy sposób odżywiania się jest bardzo ważnym elementem cyklu treningowego dziewcząt uprawiających piłkę nożną.Cel badania: poznanie...
The knowledge of women with epilepsy on motherhood/ Wiedza kobiet chorych na padaczkę na temat macierzyństwa
<b>Background:</b> Epilepsy is one of the most common neurological conditions. Approximately half of the 50 million suffering from epilepsy are women. Although the pregnancy in the course of epilepsy is considered a high...