The Association between GNB3 Gene Polymorphism and Obesity: A Systematic Review and Meta-Analysis
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2017, Vol 9, Issue 1
Abstract
The association between Guanine Nucleotide Binding protein β protein polypeptide 3(GNB3) C825T polymorphism and obesity has recently been reported. However, the findings remain inconclusive. The aim of this systematic review and meta-analysis was to detect the relationship between GNB3 C825T polymorphism and obesity. Materials and Methods: Six electronic databases including Embase, Medline, science direct and SID were investigated and searched for English articles, published before February 2016, which referred to the association between GNB3 C825T polymorphism and obesity. Pooled odds ratios (OR) with a 95% confidence interval (CI) were calculated in allele, recessive, dominant and additive genetic models to assess this association. Results: The findings demonstrated that GNB3 TT homozygote status was significantly associated with an increased risk of obesity compared with CC wild-type homozygote (TT vs. CC: OR= 1.237, 95% CI: 1.040- 1.472, P-value:0.016), while one mutation allele (TC) could not significantly increase the risk of obesity (TC vs. CC: OR= 0.91, 95% CI: 0.79- 1.05, P-value:0.207). Conclusion: Our meta-analysis suggested a significant association between the TT genotype of the GNB3 gene polymorphism and obesity risk. Thus, targeted healthcare should be strengthened with regard to this gene carrier in order to prevent obesity.
Authors and Affiliations
Narges Faramarziyan, Masoud Rahmati, Rahim Mirnasouri, Mostafa Bahrami
The Effects of Six Weeks Endurance Training on Soleus and Extensor Digitorum Longus Myonuclear Number in Diabetic Male Wistar Rats
Objective: The importance of skeletal muscle as the largest metabolic tissue in diabetes remains more unknown than other metabolic tissues of the body. The purpose of this study was to evaluate the effects of six weeks e...
Evaluation of Knowledge and Practice of Patients with Type 2 Diabetes in Tehran University Medical Sciences Hospitals-2016
Objective: Diabetes mellitus is a chronic condition becoming a worldwide health problem as a result of sedentary life style, obesity and some other risk factors. It is hypothesized that one of the barriers to achieve a p...
Distribution of ABO and Rh Blood Groups among Diabetes Type 2 Patients in Yazd Diabetes Research Center (2015-2016)
Objective: Blood group as a genetic trail can be associated with type 2 diabetes. The aim of this research was to determine the distribution of ABO frequency and RH blood groups in type 2 diabetic patients referred to Ya...
The Effect of Regular Aerobic Exercise with Garlic Extract on Heart Apoptosis Regulatory Factors in Chronic Kidney Disease
Objective: Physical activity and herbal medicine can inhabit apoptosis with two different mechanisms. The aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on heart apopt...
Fasting Blood Sugar, Glucose Challenge Test and One- Two Hour Glucose Tolerance Test in Diagnosis of Gestational Diabetes in Women without Risk Factor
Objective: Gestational diabetes mellitus (GDM) is the most common metabolic disorder during pregnancy. This study aimed to compare the prevalence of GDM positive screening tests with Fasting Blood Sugar (FBS) and Glucose...