The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency
Journal Title: Turkish Journal of Immunology - Year 2019, Vol 7, Issue 2
Abstract
ntroduction: Vitamin D is a hormone responsible in the regulation of immune response. This study was designed to assess the relationship of vitamin D deficiency on the development of infections in patients with primary immunodeficiency (PID). Materials and Methods: A total of 39 patients (M/F: 23/16) and 39 age-and sex-matched healthy controls (M/F: 23/16) were enrolled in the study. We measured the frequency of infections and serum vitamin D levels in winter and summer seasons. Results: The median age of the patient and control groups were 15.0 (Interquartile range: 7.5–26.0) years and 14.0 (9.0–25.0) years, respectively (p=0.810). Winter and summer vitamin D levels were similar both in patient and control groups (p=0.492 for winter, p=0.503 for summer). Number of the patients with low serum vitamin D levels and with infections were higher in winter than in summer. Autoimmune and inflammatory diseases (AID) were predominantly observed in patients with low winter vitamin D levels and in common variable immunodeficiency (CVID) group. Patients with CVID had lower serum vitamin D levels both in summer (p=0.048) and in winter (p=0.008). Conclusions: In this study, we showed the seasonal variation of serum vitamin D in patients with PID. There was also increased frequency of CVID and AID in those patients with low vitamin D levels. In addition, vitamin D might be given in winter to the patients with PID to take infections and autoimmune disorders under control.
Authors and Affiliations
Pınar GÜR ÇETİNKAYA, Deniz Çağdaş AYVAZ, Hacer CÜZDANCI, İlhan TEZCAN
Keywords
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- EP ID EP670730
- DOI 10.25002/tji.2019.1005
- Views 118
- Downloads 0
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