The Attenuation Effects of Apigenin, Vitexin, Hyperoside and Quercetin on Carrageenan-Induced Mice Tail Thrombosis Model
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 6
Abstract
Flavonoids exert different pharmacological actions, such as analgesic, anti-inflammatory and cardioprotective activities Apigenin, vitexin, quercetin and hyperoside are flavonoids found within medicinal plants. We aimed to study selected flavonoids’ antithrombotic effects using a carrageenan-induced tail thrombosis model in mice. To evaluate the antithrombotic effects of selected flavonoids, a carrageenan-induced tail thrombus mouse model was used. Flavonoids were administered intraperitoneally in doses of 50, 100 and 200 mg/kg. Forty μl (1%) carrageenan (type I) injected in the mouse’s hind paw 45 min after drug administration. The wine-colored region at the mouse tail was then measured at 24, 48 and 72 h. The findings showed that all flavonoids tested had antithrombotic effects. A dose of 200 mg/kg of quercetin and hyperoside decreased the length of tail thrombosis significantly (P<0.001) at day three. Apigenin and vitexin were more effective at 50 and 100 mg/kg doses than at the 200 mg/kg dose. The results obtained indicate that selected flavonoids exert preventive anticoagulant effects. Apigenin and vitexin showed antithrombotic effects at all tested doses, while quercetin and hyperoside were effective only at the highest doses. We believe that these flavonoids are promising new antithrombotic agents or could be used as complementary therapy with other anticoagulant drugs.
Authors and Affiliations
Dr. Rana ARSLAN
Keywords
Related Articles
- EP ID EP198840
- DOI -
- Views 84
- Downloads 0
Knowledge among final year student of pathological discharge in patients attending gynecology OPD
Women have so many medical problems due to the hormonal change with the age. Different abnormal discharges in women are common gynecological symptoms. Whilst most patients have benign disease, thorough investigation is n...
Silver nanoparticles, Antimicrobial activity, Delonix regia, Antioxidant activity
Karpur has been used by ancient period for promotion of pain healing. A vast drug review shows that this drug also posses analgesic activity. The analgesic effect of this plant when used in anal fissure may be of great v...
Study on traumatic rupture of tympanic membrane
Objective: To find out the causes and pattern of traumatic rupture of tympanic membrane (TM) and their prognosis. Methods: This was a cross sectional study and carried out in the otorhi-nolaryngology outpatient clinic of...
A study on association of fibrinogen and oxidative stress in prognosis of diabetic foot ulcer in tertiary government hospital
Diabetes mellitus is the most common metabolic disorder characterized by metabolic abnormalities and long term complications. Diabetic foot ulcer has poor prognosis and is a leading cause of amputation. Oxidative stress...
Removal of Mordant Green 17 and Acid Fast Red from Water using Nanokaolin
Increasing concentrations of dyes including mordant green17 and acid fast RN in surface and groundwater are a major environmental concern in recent years. In this research, the potential of nanokaolin for efficient remov...