The Auxiliary Role of Hematological Parameters in Diagnosing Localized Germ Cell Testicular Tumor
Journal Title: The Bulletin of Urooncology - Year 2020, Vol 19, Issue 4
Abstract
Objective: There is a lack of information about the relationship between germ cell testicular tumors and hematological parameters commonly used in other tumors. In this study, it was aimed to determine the value of hematological parameters used in other malignancies in the diagnosis of localized germ cell testicular cancer. Materials and Methods: Hematological parameters between patients who underwent radical orchiectomy with a pre-diagnosis of localized germ cell testicular tumor and those who underwent varicocelectomy in the same period as the control group between January 2015 and March 2019 in our clinic were compared to determine the diagnostic value of hematological parameters in testicular tumor. Results: The mean age of 39 patients diagnosed as having localized testicular tumor was 33 years. While seminoma was detected in 17 patients, non-seminomatous germ cell tumors were detected in 22 patients. In the assessment of preoperative blood samples; neutrophil count (5.6 vs 4.1, p≤0.001), neutrophil percentage (65.8 vs 57.4, p≤0.001) and neutrophil/lymphocyte ratio (2.6 vs 1.8, p≤0.001) were significantly higher, while lymphocyte ratio was significantly lower (25.3 vs 31.4, p≤0.001) in patients with testicular tumor than in the control group (n=121). In the receiver operating characteristic analysis performed for the neutrophil/ lymphocyte ratio, the cut-off point was found to be 2.25 (area under the curve =0.71, 95% confidence interval: 0.622-0.816, sensitivity: 66.7%, selectivity: 73.6%). Conclusion: Neutrophil/lymphocyte ratio, which is one of the hematological parameters, can be used as an auxiliary tool for examination and imaging methods in the diagnosis of stage I germ cell testicular tumor, which is considered to be an early stage.
Authors and Affiliations
İbrahim Kartal, Sertaç Çimen, Görkem Özenç, Alihan Kokurcan, Burhan Baylan, Nihat Karakoyunlu, Orhan Yiğitbaşı, Fatih Yalçınkaya
Keywords
Related Articles
- EP ID EP691642
- DOI 10.4274/uob.galenos.2019.1430
- Views 124
- Downloads 0
Prognostic Significance of Surgical Margin Status and Gleason Grade at the Positive Surgical Margin in Predicting Biochemical Recurrence After Radical Prostatectomy in a Turkish Patient Cohort
Objective: To investigate the prognostic role of positive surgical margin (PSM) features in addition to well-defined risk factors in predicting biochemical recurrence (BCR) after radical prostatectomy. Materials and Met...
Renal Angiomyolipoma: A Clinicopathological Study of Seven Cases and Review of the Literature
Objective: Renal angiomyolipomas (AMLs) are mesenchymal kidney tumours that have triphasic histology. This study aimed to present the clinical, pathological and immunohistochemical features of seven AML cases along with...
Changes in Metastatic Castration Sensitive Prostate Cancer
Prostate cancer is the second most common cancer in men worldwide, with approximately 1,276,106 new patients and 358,989 new deaths. Metastatic castrationsensitive prostate cancer may be de novo metastatic, but also it m...
The Relationship Between the Risk of Prostate Cancer and Second to Fourth Digit Ratio
Objective: The second to fourth digit ratio is inversely related to prenatal androgen exposure, which may be a risk factor for several androgen-dependent diseases. One of these diseases is prostate cancer (PCa). Genes th...
Second Primary Malignant Tumours in Patients with Renal Cell Carcinoma
Objective: The primary aim of our study is to establish the frequency and clinicopathological features of seconder primary malignant tumours (SPMTs) in cases with renal cell carcinoma (RCC). Materials and Methods: Patho...