The choice of fillers when creating natural zeolite tablets by the wet granulation method
Journal Title: Вісник фармації - Year 2018, Vol 96, Issue 4
Abstract
Tablets are one of the most popular among all pharmaceutical dosage forms. Properties of tablets depend on a number of factors; the content of excipients is the most important of them. Among the complex of excipients of different functional orientation fillers, which can significantly affect the technological properties of tablets, in particular, hardness and friability of tablets, occupy a special place. Aim. To to select the optimal qualitative composition of fillers for obtaining natural zeolite tablets by the method of wet granulation.Materials and methods. The objects of research were natural zeolite tablets (10 mm in diameter) obtained by pressing with the preliminary wet granulation. Model samples contained various fillers, which were the combination of lactose with microcrystalline cellulose (MCC), sorbitol and powdered sugar. A balanced single-factor experiment with equal duplication of experiments was used to select the optimal composition of excipients. Four quantitative factors were studied. The quality of the tablets was assessed by the indicators of uniformity of mass, hardness, friability and disintegration time. In the experiments the modern equipment was used. To conduct the tests the methods of the State Pharmacopoeia of Ukraine (SPhU) were used.Results and discussion. As a result of the analysis of the data obtained it has been found that both the type and concentration of fillers affect the pharmaco-technological properties of tablets. The studies conducted showed that among the types of fillers studied, including mixtures of lactose with MCC, sorbitol and powdered sugar in different proportions, the best results according to four technological factors, namely uniformity of mass, hardness, friability and disintegration time of tablets, were demonstrated by the combination of lactose with MCC in the ratio of 1 : 1. It was this combination that we chose for further research to create natural zeolite.Conclusions. The studies on selection of the qualitative composition of fillers for creation of natural zeolite tablets by pressing with the preliminary wet granulation have been performed, and the optimal composition of fillers has been proposed to provide the production of tablets which properties correspond to the current requirements of the SPhU.
Authors and Affiliations
V. D. Rybachuk
Keywords
Related Articles
- EP ID EP669235
- DOI 10.24959/nphj.18.2227
- Views 107
- Downloads 0
Система медичного постачання Збройних Сил України: фокус на інтеграцію
Метою роботи є визначення актуальних напрямків розвитку системи медичного постачання ЗС України відповідно до створеної єдиної системи логістичного забезпечення ЗС України. Матеріали та методи. Для досягнення поставленої...
Вивчення біофармацевтичних і адгезійних характеристик стоматологічного гелю
Значна поширеність стоматологічних патологій серед різних вікових груп населення Ук-раїни диктує необхідність пошуку нових ефективних лікарських засобів, що застосовуються в терапії захворювань ротової порожнини. Важливе...
Влияние препаратов производных серосодержащих аминокислот (адеметионина, таурина и глутатиона) на выживаемость животных при остром повреждении почек различного генеза
Цель работы – исследование нефропротекторной активности препаратов производных серосодержащих аминокислот (адеметионина, таурина и глутатиона) по интегральному показателю выживаемости животных на разных моделях острого п...
Разработка методов идентификации и количественного определения действующих веществ лечебно-косметического крема, предназначенного для применения в трихологии
Для профилактики и лечения андрогенной алопеции разработан лечебно-косметический крем (ЛКК) с экстрактом плодов пальмы сабаль и настойкой софоры японской. Внедрение в производство ЛКК требует его стандартизации и соответ...
The study of stability of suppositories with the glifazin herbal complex during storage
The result of the search in the direction of creating an effective and save drug for the treatment of type 2 diabetes mellitus (DM) was development of suppositories with the glifazin herbal complex obtained from the herb...