The Comparative Effect of Experimental Trypanasomosis Infection and Pantizen Treatment on the Haematological Profile of Albino Rats
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2016, Vol 13, Issue 4
Abstract
Objectives: Experimental infections of Trypanosoma brucei and Trypanosoma congolense in albino rats was done to compare their haematologic effects and then treated with Pantizen®, a brand of diminazene aceturate to ascertain its therapeutic effect on the heamatological value of the infected rats. Methods: Six groups (groups A, B, C, D, E, and F) of six albino rats each were used for the study. Group A was uninfected control. Groups B and C were single infections of T. brucei and T. congolense respectively. Group D rats were infected with T. brucei and T. congolense the same day. Group E rats infected with T. brucei first and T. congolense 7 days after. While Group F rats were infected with T. congolense first and T. brucei 7 days after. The infected rats were treated on day 14 post infection and monitored for 7 days post treatment. Packed cell volume (PCV), haemoglobin concentration (Hb), Red Blood Cell (RBC) counts, total and differential White Blood Cell counts (WBC), were monitored weekly. Results: There was significant (P < 0.05) decrease in the erythrocyte values (PCV, Hb and RBC counts) and leucocytes values, more in group D followed by groups B and E. This indicates aneamia and immunosupression respectively. However, there was no significant variation (P > 0.05) in the PCV, RBC counts and Hb conc, total leucocyte, lymphocyte, neutrophil and monocyte counts of the infected animals treated with Pantizen® especially in group E. Conclusion: It was thus concluded that the therapeutic effect of Pantizen® treatment may reverse the depletion effect of both single and mixed infections on haemo-immune system of the animal taking into consideration the parameter measured.
Authors and Affiliations
O. S. Chukwu, C. O. Ukwueze
Keywords
Related Articles
- EP ID EP329059
- DOI 10.9734/IJTDH/2016/22862
- Views 85
- Downloads 0
High Prevalence of Isolated Hepatitis B Core Antibody among Adults in Oyo State, Nigeria: The Need for Review of Diagnostic and Vaccination Guidelines
Background: Ten years of neonatal immunization with hepatitis B vaccine has not had any significant effect on the prevalence of the disease in Nigeria. Aim: To investigate hepatitis B virus (HBV) markers as potential ris...
Burden of Dengue Virus Infection in Chitwan and Peripheral Districts: An Emerging Disease in Terai Region of Nepal
Background: Dengue has become endemic and subject of concern in Terai regions of Nepal especially Chitwan and its peripheral districts. The evidence of all four serotypes of dengue virus could be a consequence of a sudde...
The Antibiotic Resisting Profile of Salmonella spp Isolated from the Sewage of the Campus of the University of Cocody, Abidjan, Côte d’Ivoire
Background: Recent studies have shown that wastewater is contaminated by salmonella sp., pathogenic antibiotics-resisting bacteria. Using wastewater in periurban agriculture in Abidjan is likely to be the source of food-...
An Audit of the Use of Renal Function Tests among Paediatric Mortalities
Background: Acute kidney injury is a frequent and serious complication encountered in critically ill children and is an independent risk factor for mortality. Major causes of childhood mortality in our environment are c...
Knowledge, Attitude and Practice on Dengue among Rural Communities in Rembau and Bukit Pelanduk, Negeri Sembilan, Malaysia
Aims: The aim of the study was to assess the level of knowledge, attitude and practices concerning dengue among rural communities of Rembau and Bukit Pelanduk district, Negeri Sembilan, Malaysia. Study Design: This was a...