The content of antimicrobial proteins in children with respiratory tract inflammatory diseases
Journal Title: Здоров`я дитини - Year 2017, Vol 12, Issue 3
Abstract
Background. Inflammatory diseases of the respiratory tract are often associated with impaired synthesis of antimicrobial peptides, whose representatives are defensins and lactoferrin (LF). The purpose of the study was to establish the concentrations of antimicrobial peptides in the oropharyngeal secretion and plasma in children with inflammatory diseases of the respiratory tract. Materials and methods. The study group included 111 children aged 4 to 17 years from orphanages. Сontent of antimicrobial proteins of LF, α-defensins 1–3 (human neutrophil peptides (HNP) 1–3), secretory immunoglobulin A in the oropharyngeal secretion, HNP 1–3 in the blood plasma, of interleukin 6 (IL-6) and -10 in the blood serum in children was measured by immunoassay. Results. Analysis of anamnestic data in somatically healthy children from orphanages showed the presence of 4 to 6 episodes of acute respiratory infections throughout the year, the duration of which averaged 5.3 ± 0.4 days. According to the results of the study, the content of α-defensins 1–3 in the blood plasma of the children of the control group was 3583.3 ± 735.4 pg/ml, while in the group of children with recurrent bronchitis, the HNP 1–3 level was almost twice higher — 6576.7 ± 602.8 pg/ml, p < 0.01. When studying the serum cytokine profile, it was found that in children with recurrent bronchitis compared with the control group, the content of proinflammatory IL-6, which regulates the inflammatory process and provides mobilization of the inflammatory response, as well as an antigen-specific immune response, had only a tendency to increase (10.1 ± 2.0 pg/ml vs 9.1 ± 1.1 pg/ml in the control group, p > 0.05). Against this background, we observed more than 3-fold increase in the level of anti-inflammatory IL-10, which is a product of type 2 helper cells, responsible for the formation of a humoral antigen-specific immune response, — 4.42 ± 1.00 pg/ml vs 1.41 ± 0.59 pg/ml, respectively (p < 0.05). Conclusions. It was found that sickly children had been characterized by the changes of mucosal protection, low content of α-defensins 1–3 in oropharyngeal secretions. The revealed changes indicated the stress of the local defense mechanisms. The investigation has revealed that overproduction of HNP 1–3 in children with recurrent bronchitis against the background of the disturbed balance between pro- and anti-inflammatory cytokines could be one of the causes of recurrent forms of the respiratory tract infection
Authors and Affiliations
G. A. Lezhenko, A. Ye. Abaturov, E. Ye. Pashkova, K. V. Gladun
Keywords
Related Articles
- EP ID EP184208
- DOI 10.22141/2224-0551.12.3.2017.104219
- Views 110
- Downloads 0
The Role of NOD-like Receptors in Recognition of Pathogen-associated Molecular Patterns of Infectious Pathogens and in Development of Inflammation Part 1. NLR family
The characteristic of the family of pattern-recognizing receptors — NLR — is presented in the review.
Gastric motility disorders in adolescents with gastroesophageal reflux disease and functional dyspepsia
Background. Gastric motility disorders in patients with upper gastrointestinal pathology are one of the key factors in the development of diseases as they disturb the well-being of patients and, therefore, require timely...
Viburcol, Engystol, Lymphomyosot — Bioregulatory Approach in Pediatric Practice
One of the most urgent problems in modern pediatrics and neonatology is the need for drugs, which, along with proven efficacy, also will be maximum safe for a growing child’s body. The article presents an overview of pub...
Isolated Pulmonary Artery Stenosis: Early Neonatal and Postnatal Diagnostics, Clinical Manifestations, Treatment and Prognosis
The article presents the published data on the prevalence, the main clinical manifestations, modern methods of early neonatal and postnatal diagnosis, treatment and prognosis of isolated pulmonary artery stenosis — a con...
Improvement of therapy for escherichiosis in children infected with Epstein-Barr virus
Background. Escherichiosis remains one of the most common intestinal infections, especially among young children. Indigestion of essential nutrients, transient fermentopathy, imbalance of the symbiotic flora, which devel...