The curious case of prion proteins:Are they a friend or foe? A review & perspective
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 1
Abstract
Transmissible spongiform encephalopathies (TSE) in humans were known to be caused by prion proteins (PrPC). Recent research has although revealed that prions are an enigmatic protein & their identity holds much more than just being causative agent of transmissible spongiform encephalopathies. Prions act as scaffolding proteins that bind ligands to the cell membrane and play an important role in signal transduction from the extracellular matrix to the cytoplasm. A major part of the neural transmission at synapse, glyapse & gap junctions is mediated by prions. It also regulates major cellular functions by regulating redox status & calcium ions flux. Considering these multiple functions of prions, in this review we focus mainly on its role in various physiological processes apart from TSE. The putataive functions of prions are indiacative of its possible role in neurodegenerative diseases, neuropathic pain, neuro inflammatory diseases & chronic headache to name a few. We also discuss the various therapeutic targets for treatment of disease influenced by prions.
Authors and Affiliations
Anirban Poddar, Samir Sahu, Subhashree Ray
Keywords
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